Identification of Multiple Complex Rearrangements Associated with Deletions in the 6q23-27 Region in Sézary Syndrome

Iżykowska, Katarzyna; Zawada, M; Nowicka, Karina; Grabarczyk, Piotr; Braun, Floriane; Delin, Martin; Möbs, Markus; Beyer, Marc; Sterry, Wolfram; Schmidt, Christian; Przybylski, Grzegorz K.

doi:10.1038/jid.2013.435

Cited by 3 publications

(3 citation statements)

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“…The 6q23‐27 region, recurrently deleted in SS, was reported in European, which involved in bi‐ and monoallelic deletions of A20 , suggesting that it may be a linker between the altered immune response and leukemogenesis . A20 is also a putative tumor suppressor in the T cell malignancy .…”

Section: Resultsmentioning

confidence: 99%

Different genetic alteration of A20 in a Sézary syndrome case with Vα2‐Jα22 T cell clone

Zhou

Zheng

Huang

et al. 2017

Asia-Pac J Clncl Oncology

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Section: Resultsmentioning

confidence: 99%

Different genetic alteration of A20 in a Sézary syndrome case with Vα2‐Jα22 T cell clone

Zhou

Zheng

Huang

et al. 2017

Asia-Pac J Clncl Oncology

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“…In human hepatocellular carcinoma (HCC), hAIG1 expression was correlated with HCC patient survival rates and thus can be used as a novel biomarker for the progression of HCC [4]. Other studies also indicated that AIG1 is involved in cancer-related processes; e.g., AIG1 can form complexes with either nuclear factor 1/B in salivary adenoid cystic carcinoma or Golgi SNAR complex member 1 in T cell lymphoma [5,6]. Zhu et al reported that when KBM7 mucells were treated with chlorpyrifos, AIG1 was required for resistance to these environmental toxicants [7].…”

Section: Introductionmentioning

confidence: 99%

Molecular Phylogenetic Analysis of the AIG Family in Vertebrates

Huang

Sun

Zhuang

et al. 2021

Genes

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Androgen-inducible genes (AIGs), which can be regulated by androgen level, constitute a group of genes characterized by the presence of the AIG/FAR-17a domain in its protein sequence. Previous studies on AIGs demonstrated that one member of the gene family, AIG1, is involved in many biological processes in cancer cell lines and that ADTRP is associated with cardiovascular diseases. It has been shown that the numbers of AIG paralogs in humans, mice, and zebrafish are 2, 2, and 3, respectively, indicating possible gene duplication events during vertebrate evolution. Therefore, classifying subgroups of AIGs and identifying the homologs of each AIG member are important to characterize this novel gene family further. In this study, vertebrate AIGs were phylogenetically grouped into three major clades, ADTRP, AIG1, and AIG-L, with AIG-L also evident in an outgroup consisting of invertebrsate species. In this case, AIG-L, as the ancestral AIG, gave rise to ADTRP and AIG1 after two rounds of whole-genome duplications during vertebrate evolution. Then, the AIG family, which was exposed to purifying forces during evolution, lost or gained some of its members in some species. For example, in eutherians, Neognathae, and Percomorphaceae, AIG-L was lost; in contrast, Salmonidae and Cyprinidae acquired additional AIG copies. In conclusion, this study provides a comprehensive molecular phylogenetic analysis of vertebrate AIGs, which can be employed for future functional characterization of AIGs.

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“…Chromosomal instability plays an important role in the pathogenesis and prognosis of this lymphoma and genetic instability has associated with a poor prognosis [19]. Recurrent regional gains are usually observed at 17q, 8q and 17p, whereas regional losses have been observed at 17p, 10q, 6q, 9q, 10p, 9p and 19p [20]. These regions are likely to contain genes involved in the development of SS.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-mediated Gene Expression in Sezary Syndrome: An Overview

Cristofoletti¹,

Picchio²,

Russo³

2015

ITI

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Abstract-Sezary syndrome (SS) is a rare leukemic cutaneous T-cell lymphoma (CTCL) with an aggressive clinical course. It is characterized by erythroderma, generalized lymphadenopathy and neoplastic skin-homing CD4+ memory T cells (Sezary cells) in the skin, lymph nodes, and peripheral blood. Despite the availability of a number of active systemic therapeutic strategies, SS remains an incurable lymphoma. Recently, high throughput analyses have revealed a novel approach to identify the molecular process implicated in the development and tumorigenesis of SS, which is relevant to a pharmacological therapeutic strategy. The aim of this review is to describe some altered genes, starting from the main deregulated microRNAs discovered in SS.

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Identification of Multiple Complex Rearrangements Associated with Deletions in the 6q23-27 Region in Sézary Syndrome

Abstract: Figure 3g of this article was published with the legend labels inverted. The open bar should read ''Wild type'' and the solid bar should read ''TLR4 deficient''. The corrected figure appears below. The publisher regrets the error.

Cited by 3 publications

References 0 publications

Different genetic alteration of A20 in a Sézary syndrome case with Vα2‐Jα22 T cell clone

Different genetic alteration of A20 in a Sézary syndrome case with Vα2‐Jα22 T cell clone

Molecular Phylogenetic Analysis of the AIG Family in Vertebrates

MicroRNA-mediated Gene Expression in Sezary Syndrome: An Overview

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