Identification of Modules Related to Programmed Cell Death in CHD Based on EHEN

Abstract

The formation and death of macrophages and foam cells are one of the major factors that cause coronary heart disease (CHD). In our study, based on the Edinburgh Human Metabolic Network (EHMN) metabolic network, we built an enzyme network which was constructed by enzymes (nodes) and reactions (edges) called the Edinburgh Human Enzyme Network (EHEN). By integrating the subcellular location information for the reactions and refining the protein-reaction relationships based on the location information, we proposed a computational approach to select modules related to programmed cell death. The identified module was in the EHEN-mitochondria (EHEN-M) and was confirmed to be related to programmed cell death, CHD pathogenesis, and lipid metabolism in the literature. We expected this method could analyze CHD better and more comprehensively from the point of programmed cell death in subnetworks.

Quantitative Identification of Compound‐Dependent On‐Modules and Differential Allosteric Modules From Homologous Ischemic Networks

“…Module‐based methods have made much progress in deconstructing complex networks and may contribute substantially to rational drug design in the context of modular pharmacology . Several studies have attempted to identify module biomarkers or targets for cancers and many other diseases . Causal coexpression methods with module analysis have been applied to screen drugs with specific targets and fewer side effects .…”

Catechol-O-methyltransferase promoter hypomethylation is associated with the risk of coronary heart disease

“…Coronary heart disease (CHD) is typically caused by arteriosclerosis, which is characterized by the narrowing or blockage of coronary arteries (1). CHD is a complex disease, and a variety of genetic and epigenetic factors have been associated with an increased risk of CHD (2)(3)(4).…”