Identification of miR-130a, miR-27b and miR-210 as serum biomarkers for atherosclerosis obliterans

Li, Tianrun; Cao, Heng-Chang; Zhuang, Jinman; Wan, Jun; Guan, Ming; Yu, Bo; Liu, Xuan; Zhang, Wei

doi:10.1016/j.cca.2010.09.029

Cited by 193 publications

(151 citation statements)

References 26 publications

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“…In order to identify a specific and sensitive biomarker for ASO, using tissue samples and blood samples obtained from ASO patients, Li et al examined the expression levels of a series of miRNAs. The results identified a significant increase in miR-130a, miR-27b and miR-210 expression, which was positively correlated with the Fontaine stage (59). Therefore, the serum and tissue levels of these miRNAs serve as potential biomarkers for early stage PAD.…”

Section: Mirnas and Padmentioning

confidence: 87%

“…The results of those authors suggested that miR-21 is capable of regulating ASMC function by targeting tropomyosin 1, and the hypoxia inducible factor-1α/miR-21/tropomyosin 1 pathway may play a critical role in the pathogenesis of ASO (58). Specific signatures of miRNAs may be obtained from total serum/plasma or tissues and are able to be used in the identification of biomarkers for the diagnosis, prognosis or even the etiology of a disease (59). Currently, miRNAs have become a hot topic as biomarkers and therapeutic targets for cardiovascular disease (60).…”

Section: Mirnas and Padmentioning

confidence: 99%

“…Currently, miRNAs have become a hot topic as biomarkers and therapeutic targets for cardiovascular disease (60). Caporali et al (59) revealed that miR-503 was highly expressed in ischemic muscle specimens and the plasma of diabetic patients with critical limb ischemia. Their study provided evidence for a role of miR-503 in DM-induced endothelial defects contributing to impaired postischemic angiogenesis, and also demonstrated that the overexpression of miR-503 inhibited EC proliferation, migration and network formation, and reduced VSMC proliferation and migration.…”

Section: Mirnas and Padmentioning

confidence: 99%

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Role of microRNAs in peripheral artery disease (Review)

Zhou¹,

Yuan²,

He³

2012

Molecular Medicine Reports

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Abstract. Peripheral arterial disease (PAD) involves a general vascular problem of diffuse atherosclerosis. The key pathological process is characterized by the aberrant proliferation of vascular smooth muscle cells and the formation of neointimal lesions. The molecular mechanisms involved in the regulation of the occurrence and development of PAD remain unclear. microRNAs (miRNAs) are highly conserved 20-25 nt-long non-coding RNAs that negatively regulate gene expression. Recent evidence has demonstrated that specific miRNAs are involved in the pathological processes of PAD, and these miRNAs are found to be critical modulators of vascular cell functions, including cell differentiation, contraction, migration, proliferation and apoptosis. This review summarizes findings of studies regarding the roles of specific miRNAs in PAD.

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Section: Mirnas and Padmentioning

confidence: 87%

Section: Mirnas and Padmentioning

confidence: 99%

Section: Mirnas and Padmentioning

confidence: 99%

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Role of microRNAs in peripheral artery disease (Review)

Zhou¹,

Yuan²,

He³

2012

Molecular Medicine Reports

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“…When the association between dysregulated miRNAs and echocardiographic findings was investigated, miR-182 (r = -0.305; p = 0.04), miR-200a* (r = -0.360; p = 0.019), and miR-568 (r = -0.350; p = 0.023) were found to be inversely correlated with LVMI, while miR-155 (r = 0.361; p = 0.019) and miR-595 (r= 0.305; p = 0.04) were determined to be positively correlated with LVMI (Table 4). 21.5 µL of total biotin-labelled RNA, 50 µL hybridisation mix, 15 µL formamide, 10 µL DMSO, 5 µL eukaryotic hybridisation controls, and 1.7 µL control oligonucleotide B2). Immediately after hybridisation the arrays were washed and stained with streptavidin phycoerythrin conjugate to remove nonspecific binding.…”

Section: Microarray Proceduresmentioning

confidence: 99%

“…It is also highly expressed in various types of cancer tissues and cell lines and plays a pivotal role in stress response and pathological cell growth [20]. Moreover, it was found to be upregulated in peripheral artery disease by Li et al [21].…”

Section: Variablesmentioning

confidence: 99%

The relationship between circulating microRNAs and left ventricular mass in symptomatic heart failure patients with systolic dysfunction

et al. 2015

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A b s t r a c tBackground: In recent years, many microRNAs (miRNAs) were shown to be dysregulated in specific tissues playing critical roles in the pathogenesis and progression of heart failure (HF). Left ventricular (LV) mass (LVM) has long been recognised as an important prognostic marker in systolic HF patients. Aim:We hypothesised that circulating miRNAs may be associated with LVM in systolic HF patients. The present study aimed to evaluate the relationship between previously reported and novel dysregulated circulating miRNAs and echocardiographically determined LVM in symptomatic HF patients with LV systolic dysfunction.Methods: Forty-two consecutive patients diagnosed with NYHA II-IV symptomatic systolic HF and a control group consisting of 15 age-and sex-matched healthy volunteers were enrolled. After labelling extracted RNA, poly-A tails were added. RNAs were later hybridised on a GeneChip miRNA 2.0 array. After hybridisation and staining, arrays were scanned to determine miRNA expression levels, and differentially expressed miRNAs were identified.Results: Eighteen miRNAs were found to be upregulated in serum of HF patients, while 11 were demonstrated to be downregulated. When the association between dysregulated miRNAs and echocardiographic findings was investigated, miR-182 (p = 0.04), miR-200a* (p = 0.019), and miR-568 (p = 0.023) were found to be inversely correlated with LVM index (LVMI), while miR-155 (p = 0.019) and miR-595 (p = 0.04) were determined to be positively correlated with LVMI. Conclusions:The results of our study revealed that dysregulated circulating miRNAs were correlated with anatomic changes in LV, in terms of LVMI, in symptomatic HF patients with systolic LV dysfunction.

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Micromanaging Atherogenesis

Wang

Anderson

2015

Atherosclerosis

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Identification of miR-130a, miR-27b and miR-210 as serum biomarkers for atherosclerosis obliterans

Cited by 193 publications

References 26 publications

Role of microRNAs in peripheral artery disease (Review)

Role of microRNAs in peripheral artery disease (Review)

The relationship between circulating microRNAs and left ventricular mass in symptomatic heart failure patients with systolic dysfunction

Micromanaging Atherogenesis

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