Identification of microRNAs associated with abdominal aortic aneurysms and peripheral arterial disease

Stather, P.W.; Sylvius, Nicolas; Sidloff, David; Dattani, Nikesh; Verissimo, Ana Raquel; Wild, John B.; Butt, H.Z.; Choke, Edward; Sayers, Robert D.; Bown, Matthew J.

doi:10.1002/bjs.9802

Cited by 57 publications

(32 citation statements)

References 43 publications

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“…MiR‐24 is significantly decreased in both tissue and plasma of AAA patients and is inversely related to the size of the AAA 192. Recently, miR‐33a‐5p, let‐7i‐5, miR‐652‐3p and miR‐331‐3p are elevated in plasma of AAA patients compared with healthy controls, and miR‐192‐5p, miR‐10b‐5p, miR‐194‐5p, miR‐215‐5p, miR‐205‐5p, miR‐16‐5p, miR‐126, miR‐124a, miR‐155, miR‐223, miR‐29b, miR‐15a and miR‐15b are decreased 191, 193. However, miR‐29b was up‐regulated in human tissues from thoracic AA patients 187.…”

Section: Clinical Value Of Mirnas As New Biomarkers For Angiogenesis‐mentioning

confidence: 98%

“…Additionally, the expression of miR‐146a is different in different types of samples from AAA patients. It is increased in AAA tissues 188 but is decreased in plasma of AAA patients 191. This may be because of different sources of sample and disease characteristics.…”

Section: Clinical Value Of Mirnas As New Biomarkers For Angiogenesis‐mentioning

confidence: 99%

“…Of note, down‐regulation of miR‐133a and miR‐133b is involved with a shift of VSMCs to a proliferative phenotype,190 and the decreased miR‐204 level can improve MMP‐9 in human AAA tissue, and thereby enhance the degradation of the extracellular matrix in AAA. In addition, miR‐411 is significantly increased in whole blood samples of patients with abdominal aortic aneurysm (AAA) compared with controls, and let‐7e, miR‐15a and miR‐196 are significantly decreased 191. MiR‐24 is significantly decreased in both tissue and plasma of AAA patients and is inversely related to the size of the AAA 192.…”

Section: Clinical Value Of Mirnas As New Biomarkers For Angiogenesis‐mentioning

confidence: 99%

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The regulatory role of microRNAs in angiogenesis‐related diseases

Sun

Lei

et al. 2018

J Cellular Molecular Medi

117

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MicroRNAs (miRNAs) are small non‐coding RNAs that regulate gene expression at a post‐transcriptional level via either the degradation or translational repression of a target mRNA. They play an irreplaceable role in angiogenesis by regulating the proliferation, differentiation, apoptosis, migration and tube formation of angiogenesis‐related cells, which are indispensable for multitudinous physiological and pathological processes, especially for the occurrence and development of vascular diseases. Imbalance between the regulation of miRNAs and angiogenesis may cause many diseases such as cancer, cardiovascular disease, aneurysm, Kawasaki disease, aortic dissection, phlebothrombosis and diabetic microvascular complication. Therefore, it is important to explore the essential role of miRNAs in angiogenesis, which might help to uncover new and effective therapeutic strategies for vascular diseases. This review focuses on the interactions between miRNAs and angiogenesis, and miRNA‐based biomarkers in the diagnosis, treatment and prognosis of angiogenesis‐related diseases, providing an update on the understanding of the clinical value of miRNAs in targeting angiogenesis.

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Section: Clinical Value Of Mirnas As New Biomarkers For Angiogenesis‐mentioning

confidence: 98%

Section: Clinical Value Of Mirnas As New Biomarkers For Angiogenesis‐mentioning

confidence: 99%

Section: Clinical Value Of Mirnas As New Biomarkers For Angiogenesis‐mentioning

confidence: 99%

See 1 more Smart Citation

The regulatory role of microRNAs in angiogenesis‐related diseases

Sun

Lei

et al. 2018

J Cellular Molecular Medi

117

View full text Add to dashboard Cite

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“…Zhang et al identified increased expression of miR-191-3p, -455-3p, and -1281 in the whole blood of AAA patients compared to controls, while a separate study showed decreased expression of miR-126, -124a, -146a, -155, -223, -29b, -15a, and -15b in AAA [164, 165]. Stather et al reported reduced expression of let-7e, miR-15a, and -196b in the peripheral blood of AAA patients and increased expression of miR-411 as compared to controls [165]. The increased expression of some miRNA in AAA tissue and decreased expression in peripheral blood (i.e., miR-146a and miR-29b) demonstrate the complex nature of using miRNA as biomarkers of disease progression.…”

Section: Epigenetic Risk Factorsmentioning

confidence: 99%

Genetic and Epigenetic Regulation of Aortic Aneurysms

Kim

Stansfield

2017

BioMed Research International

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Aneurysms are characterized by structural deterioration of the vascular wall leading to progressive dilatation and, potentially, rupture of the aorta. While aortic aneurysms often remain clinically silent, the morbidity and mortality associated with aneurysm expansion and rupture are considerable. Over 13,000 deaths annually in the United States are attributable to aortic aneurysm rupture with less than 1 in 3 persons with aortic aneurysm rupture surviving to surgical intervention. Environmental and epidemiologic risk factors including smoking, male gender, hypertension, older age, dyslipidemia, atherosclerosis, and family history are highly associated with abdominal aortic aneurysms, while heritable genetic mutations are commonly associated with aneurysms of the thoracic aorta. Similar to other forms of cardiovascular disease, family history, genetic variation, and heritable mutations modify the risk of aortic aneurysm formation and provide mechanistic insight into the pathogenesis of human aortic aneurysms. This review will examine the relationship between heritable genetic and epigenetic influences on thoracic and abdominal aortic aneurysm formation and rupture.

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“…71 Recently, many investigators have reported circulating micro-RNAs associated with AAA presence, such as miR-155, miR-191-3p, miR-455-3p, miR-1281, and miR-411. [72][73][74] Theoretical micro-RNAs have advantages over other circulating nucleic acids as markers in diagnostic tests because of their stability in blood samples. There have also been studies using lipidomics.…”

Section: Future Progress In Identifying Circulatingmentioning

confidence: 99%

Surrogate Markers of Abdominal Aortic Aneurysm Progression

Wanhainen

Mani

Golledge

2016

ATVB

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Abstract-The natural course of many abdominal aortic aneurysms (AAA) is to gradually expand and eventually rupture and monitoring the disease progression is essential to their management. In this publication, we review surrogate markers of AAA progression. AAA diameter remains the most widely used and important marker of AAA growth. Wanhainen et al Surrogate Markers of Aneurysm Progression 237in all studies when a standardized protocol is used. 7,8 One of the challenging aspects to assessing maximum AAA diameter is the variety of methods that can potentially be used and the lack of reporting of the exact techniques used in individual studies. Variations may occur in the plane of acquisition (eg, coronal or sagittal), the axis of measurement (eg, axial or orthogonal), the position of the measuring calipers (eg, inner to inner or outer to outer), the relationship with the cardiac cycle (systole versus diastole), and the selected region of the AAA. 9 It has been suggested that diameters measured perpendicular to the aorta centerline (orthogonal), rather than within the axial plane, are more representative of the true AAA diameter. 4,6 With ultrasound, measurements within the anteroposterior, rather than the transverse plane, have been reported to be more reproducible. 4 There is no current consensus on how to place the calipers when measuring the diameter with ultrasound. Methods used include the outer-to-outer method, where calipers are placed on the outer layer of the aortic wall; the inner-to-inner method, where calipers are placed on the inner layer of the aortic wall; and the leading edge-to-leading edge method, where calipers are placed on the outer layer of the anterior wall and the inner layer of the posterior wall ( Figure 1). Much of the reported variation in ultrasound measured AAA diameter is likely because of the variation in caliper placement. 5,10 The UK Small Aneurysm Trial 11 is based on the measurement of AAA diameter on the outer-to-outer method, and this method has been adopted into the current UK intervention criteria. 12 The inner-to-inner method was used in the Multicentre Aneurysm Screening Study, 13 and consequently it is used in the current UK National Health Service AAA screening programme.14 The leading edgeto-leading edge method is used in the current Swedish AAA screening programme.15 Studies comparing these methods show there is a significant difference in diameters measured with the different methods, which has an impact on the reported prevalence rates of AAA. 5,10 In a Swedish AAA screening study, the difference in mean diameter was 4 mm between inner-toinner and outer-to-outer, which resulted in an astonishing 77% difference in AAA prevalence (ie, 1.3% compared with 2.3%). 5A systematic review of 15 studies reported considerable variation in small AAA growth rates (mean, −0.3 to +4.0 mm/y). 15 The variation could not be explained by differences in initial AAA diameter alone. 16 The authors suggested that methodological issues, such as differences in imaging modalities, variation ...

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Identification of microRNAs associated with abdominal aortic aneurysms and peripheral arterial disease

Cited by 57 publications

References 43 publications

The regulatory role of microRNAs in angiogenesis‐related diseases

The regulatory role of microRNAs in angiogenesis‐related diseases

Genetic and Epigenetic Regulation of Aortic Aneurysms

Surrogate Markers of Abdominal Aortic Aneurysm Progression

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