“…Recent developments in SALDI-MS technique involve the design of surfaces/substrates for efficient detection of organic and inorganic compounds for applications including, but not limited to pharmaceutical, 14 proteomics (peptides and proteins), 15 biological, 16 and forensics. 17 Materials such as silicon-based ( e.g ., desorption/ionization on silicon; DIOS), 18–20 organic-based ( e.g ., immobilized carbon nanotubes, 21 activated carbon surface, 22 oxidized graphitized carbon black, 23 ) metal-based/metal-oxide ( e.g ., Au, 24 Pd, 25 Pt, 26–27 HgSe, 28 titania nanotube arrays, 29 TiO 2 , 30–31 MgO, 32 lithium-rich composite metal oxide 33 ), metal-organic frameworks, 34–36 quantum dots, 37 and multilayer-coated ( e.g ., two-layered amorphous silicon 38 , MoS 2 /TiO 2 /SiNW surface 39 ) have been utilized as surfaces for SALDI with advantages including high absorption coefficient for laser energy and low matrix interferences. Some of these SALDI surfaces are modified or functionalized to increase selectivity or to serve as affinity probes for enhanced MS detection.…”