Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow

Derivation and immunological characterization of mesenchymal stromal cells from human embryonic stem cells

“…Over the last several years MSCs have been derived from a variety of other tissues of adult [5][6][7] or fetal origin [8,9]. Interestingly, these MSCs have also been shown to have a wider differentiation capability in vitro and in vivo than previously appreciated, at least in some experimental models, [10][11][12] and thus have attracted attention as very desirable cells for regenerative medicine.…”

Mesenchymal stem cells derived from human placenta suppress allogeneic umbilical cord blood lymphocyte proliferation

“…Human mesenchymal stem cells (MSC), which are first isolated from bone marrow (BM) [1,2] and subsequently isolated from other tissues such as adipose tissue, cutaneous tissue, fetal hepatic and pulmonary tissue [3][4][5][6][7][8][9][10][11], are pluripotent progenitors for a variety of tissues including bone, cartilage, tendon, fat, and muscle [12]. It has been approved have the capability to support expansion of hematopoietic stem cells (HSC) through expressing cytokines and reconstructing hematopoietic microenvironment [13,14].…”

Skeletal tissue engineering using embryonic stem cells

“…Cell-based bone tissue engineering might result in better bone healing and several cell types have been investigated. [68], fetal blood and liver [69], peripheral blood [70], umbilical cord [71], placenta [72], amniotic fluid [73,74] and human embryonic germ cells [75]. The low frequency and limited proliferative capacity are drawbacks of adult stem cells.…”