Identification of membrane-associated lymphotoxin (LT) on mitogen-activated human lymphocytes using heterologous anti-LT antisera in vitro

The unexpected role of lymphotoxin β receptor signaling in carcinogenesis: from lymphoid tissue formation to liver and prostate cancer development

“…Interestingly, murine and human TNFa and b genes are close to each other within the major histocompatibility complex region (mouse, chromosome 17 (Nedospasov et al, 1986a, b); man, short arm of chromosome 6 (Nedwin et al, 1985b;Muller et al, 1987)). Later a third ligand-homologous to TNFb-was identified within the major histocompatibility complex locus and named LTb (TNFSF3; (Hiserodt et al, 1977;Ware and Granger, 1979;Browning et al, 1993;Pokholok et al, 1995), whereas subsequently TNFb was termed LTa or TNFSF1B. At present, 19 different ligands belong to the TNFSF, including, for example, TRAIL, RANKL, BAFF, CD40 (Aggarwal, 2003), mediating their cellular response through 29 receptors, which contain an extracellular cysteine-rich domain (Aggarwal, 2003) and in some cases (for example, TNFR1, TNFR2, TRAIL R1, TRAIL R2, Fas) a death domain.…”