Identification of markers of opportunistic infections and viral hepatitis in oncohematological patients

Abstract

The purpose of the study To estimate the prevalence of markers of herpesvirus infections and pneumocystosis in patients of the hematological department. To identify whether the contamination of hematological patients with hepatitis B and C (HBV, HCV) affects on the activation of opportunistic infections (OIs). Materials and methods There were examined 94 patients of the hematological department, including 48 patients with markers of HBV infection and 46 cases without them. Obtained results Markers of acute OIs (simple herpes virus type 1- 6,4%, EBV - 14,9%, CMV - 6,4%, and Human Herpesvirus 6- 13,8% and 33,0% of pneumocystosis) in hematological patients were determined more frequently than in donors. Comparative analysis of the data revealed the excess of the proportion of cases with markers of acute HHV-6 infection in hematological HBV patients in comparison with a group of hematologic patients without markers of HBV infection (22,9% against 4,4%, p

Viral hepatitis B in patients with hematological malignancies (Overview)

“…A statistically and clinically signifi cant increase in the proportion of individuals with markers of acute HHV-6 infection among hematological patients infected with HBV was revealed. Interestingly, no such pattern was found in relation to other herpes viruses (HSV-1,2, CMV, EBV) [14].…”