Identification of major rice allergen and their clinical significance in children

Jeon, Young Tae; Oh, Se Jo; Yang, Hyeon Jong; Lee, Soo Young; Pyun, Bok Yang

doi:10.3345/kjp.2011.54.10.414

Cited by 10 publications

(7 citation statements)

References 25 publications

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“…In addition to these large-scale studies, several small studies have assessed individual FA and major food allergens, re-evaluated the diagnostic decision point of food-specific IgE antibodies, or presented detailed case studies of the clinical and laboratory characteristics of FA in Korean children 17 25 26 27 28 29 30 31 32 33 34 35) .…”

Section: Main Triggers Of Ige-mediated Fa In Childrenmentioning

confidence: 99%

IgE-mediated food allergies in children: prevalence, triggers, and management

Lee

2017

Korean J Pediatr

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Food allergy (FA) is a serious health problem, and severe FA such as food-induced anaphylaxis can often be life threatening. The incidence of FA has been increasing especially in children. They usually develop early in life and affect up to 10% of children. The 2 most common food allergens worldwide are milk and eggs, while the third one varies depending on the countries: peanuts in the United States and Switzerland, wheat in Germany and Japan, tree nuts in Spain, sesame in Israel, and walnuts in Korea. These common food allergens are different and difficult to identify because of differing study methodologies, population, geography, age, and dietary exposure patterns. The current management of FA relies on the strict avoidance of culprit allergens, the prompt treatment of allergic reactions, including epinephrine use for food-induced anaphylaxis, monitoring, and education to prevent further reactions. Newer approaches for tolerance induction to FA and FA immunotherapy have been under investigation but are not yet ready for real-world application. Thus, consistent and systematic education of patients, caregivers, and food-handling people is of primary importance for the management and prevention of FA reactions. This review assesses and compares IgE-mediated FA in children in Korea and other countries, with a focus on summarizing the prevalence, common triggers, and management of FA.

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Section: Main Triggers Of Ige-mediated Fa In Childrenmentioning

confidence: 99%

IgE-mediated food allergies in children: prevalence, triggers, and management

Lee

2017

Korean J Pediatr

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“…However there has been an increase of non-specific sensitization in Korean children, without clinical symptoms. So, we tried to determine the major IgE binding components in rice extract and their clinical significance [45]. Twenty-four children (15 boys and 9 girls; mean age, 16.3 months) with allergic disease, who were sensitized to rice antigen confirmed by ImmunoCAP in the Pediatric Allergy Respiratory Center at Soonchunhyang University Hospital, were enrolled.…”

Section: Plant Fa In Korean Childrenmentioning

confidence: 99%

IgE mediated food allergy in Korean children: focused on plant food allergy

Lee

2013

Asia Pacific Allergy

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Food allergy (FA) is a worldwide problem, with increasing prevalence in many countries, and it poses a clearly increasing health problem in Korea. In Korea, as a part of International Study of Asthma and Allergy in Childhood (ISAAC), a series of nation-wide population studies for prevalence of allergic disease in children were carried out, with the Korean version of ISAAC in 1995, 2000, and 2010. From the survey, the twelve-month prevalence of FA showed no significant differences from 1995 to 2000 in both age groups (6-12 years-old, 6.5% in 1995 and 5.7% in 2000; 12-15 year-olds, 7.4% in 1995 and 8.6% in 2000). The mean lifetime prevalence of FA which had ever been diagnosed by medical doctor was 4.7% in 6-12 year-olds and 5.1% in 12-15 year-olds respectively in 2000. In Korean children, the major causes of FA are almost same as in other countries, although the order prevalence may vary, a prime example of which being that peanut and tree nut allergies are not prevalent, as in western countries. Both pediatric emergency department (ED) visits and deaths relating to food induced anaphylaxis have also increased in western countries. From a study which based on data from the Korean Health Insurance Review and Assessment Service (KHIRA) from 2001 to 2007, the incidence of anaphylaxis under the age of 19 was 0.7-1 per 100,000 person-year, and foods (24.9%) were the most commonly identified cause of childhood anaphylaxis. In another epidemiologic study, involving 78889 patients aged 0-18 years who visited the EDs of 9 hospitals during June 2008 to Mar 2009, the incidence of food related anaphylaxis was 4.56 per 10,000 pediatric ED visits. From these studies, common causes of food related anaphylaxis were seafood, buckwheat, cow's milk, fruits, peanut and tree nuts. Although systematic epidemiologic studies have not reported on the matter, recently, plant foods related allergy has increased in Korean children. Among 804 children with moderate to severe atopic dermatitis, we reveals that the peanut sensitization rate in Korea reaches 18%, and that, when sensitized to peanut, patients showed a significant tendency to have co-sensitization with house dust mites, egg white, wheat, and soybean. The higher specific IgE to peanut was related to the likelihood of the patient developing severe systemic reactions. In another study, based on the data analysis of 69 patients under 4 years of age who had suspected peanut and tree nut allergy, 22 (31.9%) were sensitized to walnut (>0.35 kU/L, 0.45-27.4 kU/L) and 6 (8.7%) experienced anaphylaxis due to a small amount of walnut exposure. Furthermore, in this review, clinical and immunological studies on plant food allergies, such as buckwheat allergy, rice allergy, barley allergy, and kiwi fruit allergy, in Korean children are discussed.

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“…Others have also documented the reactivity of the 56 kDa rice protein to IgE antibodies from rice-allergic patients. 20,21 However, until now, the identity of the 56 kDa allergen has not been known.…”

Section: ■ Introductionmentioning

confidence: 99%

Identification of an Abundant 56 kDa Protein Implicated in Food Allergy as Granule-Bound Starch Synthase

Krishnan

Chen

2013

J. Agric. Food Chem.

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Rice, the staple food of south and east Asian counties, is considered to be hypoallergenic. However, several clinical studies have documented rice-induced allergy in sensitive patients. Rice proteins with molecular weights of 14-16, 26, 33, and 56 kDa have been identified as allergens. Recently, it was documented that the 56 kDa rice allergen was responsible for rice-induced anaphylaxis. The 14-16 kDa allergens have been identified as α-amylase inhibitors; the 26 kDa protein has been identified as α-globulin; and the 33 kDa protein has been identified as glyoxalase I. However, the identity of the 56 kDa rice allergen has not yet been determined. In this study, we demonstrate that serum from patients allergic to maize shows IgE binding to a 56 kDa protein that was present in both maize and rice but not in the oil seeds soybean and peanut. The 56 kDa IgE-binding protein was abundant in the rice endosperm. We have purified this protein from rice endosperm and demonstrated its reactivity to IgE antibodies from the serum of maize-allergic patients. The purified protein was subjected to matrix-assisted laser desorption ionization-time of flight-tandem mass spectrometry analysis, resulting in identification of this rice allergen as granule-bound starch synthase, a product of the Waxy gene. Immunoblot analysis using protein extracts from a waxy mutant of rice revealed the absence of the 56 kDa IgE-binding protein. Our results demonstrate that the 56 kDa rice allergen is granule-bound starch synthase and raise the possibility of using waxy mutants of rice as a potential source of the hypoallergenic diet for patients sensitized to the 56 kDa rice allergen.

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Identification of major rice allergen and their clinical significance in children

Cited by 10 publications

References 25 publications

IgE-mediated food allergies in children: prevalence, triggers, and management

IgE-mediated food allergies in children: prevalence, triggers, and management

IgE mediated food allergy in Korean children: focused on plant food allergy

Identification of an Abundant 56 kDa Protein Implicated in Food Allergy as Granule-Bound Starch Synthase

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