Identification of Loliolide with Anti-Aging Properties from Scenedesmus deserticola JD052

Abstract

Herein, different extracts of Scenedesmus deserticola JD052, a green microalga, were evaluated in vitro as a potential anti-aging bioagent. Although post-treatment of microalgal culture with either UV irradiation or high light illumination did not lead to a substantial difference in the effectiveness of microalgal extracts as a potential anti-UV agent, the results indicated the presence of a highly potent compound in ethyl acetate extract with more than 20% increase in the cellular viability of normal human dermal fibroblasts (nHDFs) compared with the negative control amended with DMSO. The subsequent fractionation of the ethyl acetate extract led to two bioactive fractions with high anti-UV property; one of the fractions was further separated down to a single compound. While electrospray ionization mass spectrometry (ESI-MS) and nuclear magnetic resonance (NMR) spectroscopy analysis identified this single compound as loliolide, its identification has been rarely reported in microalgae previously, prompting thorough systematic investigations into this novel compound for the nascent microalgal industry.

IL-6 Inhibitory Compounds from the Aerial Parts of Piper attenuatum and Their Anticancer Activities on Ovarian Cancer Cell Lines

“…In plants, (-)-loliolide serves as a defensive molecule against pathogens and herbivores and possesses allelopathic effects, such as germination and growth inhibition in other plants [39]. (-)-Loliolide has been shown to have several biological activities [40][41][42][43], but no studies on its anticancer effects have been reported. While research on the biological activities of Piper species has focused heavily on alkaloids, (-)-loliolide highlights the importance of investigating other secondary metabolites for potential benefits.…”

Loliolide in Sargassum horneri Alleviates Ultrafine Urban Particulate Matter (PM 0.1)-Induced Inflammation in Human RPE Cells

“…S. horneri contains bioactive compounds, such as fucoidan and loliolide, with promising bioactivities, such as antioxidant and anti-inflammatory functions [ 15 ]. In particular, loliolide, the phenolic compound known as one of the active ingredients of S. horneri , is reported to have a variety of functions, such as cell protection, anti-cancer, anti-aging, and anti-apoptosis activities, including antioxidant and anti-inflammatory functions [ 16 , 17 , 18 ]. Furthermore, many studies have suggested that S. horneri is a potential inhibitor of PM-induced inflammatory responses, oxidative stress, and cell death [ 19 , 20 ].…”

Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis

“…[102,103] Glutamic acid Anticancer, antimicrobial, nephroprotection, and antidiabetic[37,45] Jujubogenin Anti-inflammatory and antioxidant[104,105] Loliolide Anti-aging, antioxidant, anti-inflammatory, neuroprotector, anti-Parkinson, anticholinesterase and antidepressant[37,106] Pseudojujubogenin glycoside Anti-ageing, anticancer, anticonvulsant, antidepressant, anti-emetic, antiinflammatory. and antibacterial[102,103] Glutamic acid Anticancer, antimicrobial, nephroprotection, and antidiabetic [37,45] Jujubogenin Anti-inflammatory and antioxidant [104,105] Loliolide Anti-aging, antioxidant, anti-inflammatory, neuroprotector, anti-Parkinson, anticholinesterase and antidepressant [37,106] Pseudojujubogenin glycoside Anti-ageing, anticancer, anticonvulsant, antidepressant, anti-emetic, antiinflammatory.…”