Identification of LncRNAs/mRNAs related to endometrium function regulated by Homeobox A10 in Ishikawa cells

Lin, Ruiyi; Zhao, Changzhi; Lü, Jing; Zhao, Shuhong

doi:10.1002/cbin.10458

Cited by 5 publications

(2 citation statements)

References 42 publications

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“…LINC00641 has been reported to be one of the 20 differentially expressed LncRNAs and mRNAs dysregulated through HOXA10 overexpression; for example, in one study, it showed downregulation with fold changes ≥ 2 and P < 0.05 ( 47 ). On the other hand, much evidence shows that several homeobox genes such as HOXA10 are dysregulated in cancers, significantly contributing to tumor progression.…”

Section: Discussionmentioning

confidence: 99%

JPX and LINC00641 ncRNAs expression in prostate tissue: a case-control study

2021

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Background and purpose: Prostate cancer (PC) is the second most prevalent cancer in men. Prostate-specific antigen (PSA) is the main biomarker for screening PC. An increase in PSA could lead to false-positive results. Thus, more appropriate markers should be investigated. In the present study, JPX and LINC00641 expression levels were measured in tumoral prostate tissue compared with the non-tumor tissue. Experimental approach: 43 pairs of prostate tumoral and non-tumor tissue were prepared. The expression levels of JPX and LINC00641 were investigated by RT-qPCR. Findings/Results: Significant upregulation of LINC00641 (2.47 ± 0.5 vs 1.41 ± 0.2) and downregulation of JPX (1.42 ± 0.6 vs 2.83 ± 1.0) were observed in PC tissues compared with the normal tissues (their adjacent non-tumoral tissues). Conclusion and implications: Dysregulation of JPX and LINC00641 in PC patients could be used in the future as a prognostic biomarker in PC.

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Section: Discussionmentioning

confidence: 99%

JPX and LINC00641 ncRNAs expression in prostate tissue: a case-control study

2021

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“…The transcription factor HOXA10, which is important in fertility through affecting endometrial decidualization and embryo implantation, is also capable of significantly altering mRNA and lncRNA expression involved in the processes of blood vessel development, cell cycle and oocyte meiosis. Thus, lncRNAs are necessary in the normal physiology of women, in preparation for pregnancy (Lin et al, ). Expression profiles of lncRNAs were altered in patients with endometriosis, compared to healthy individuals.…”

Section: Lncrnas In Wnt‐mediated Pathogenesis In Female Reproductive mentioning

confidence: 99%

‘Lnc’‐ing Wnt in female reproductive cancers: therapeutic potential of long non‐coding RNAs in Wnt signalling

Ong

Cai

Yuan

et al. 2017

British J Pharmacology

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Recent discoveries in the non-coding genome have challenged the original central dogma of molecular biology, as non-coding RNAs and related processes have been found to be important in regulating gene expression. MicroRNAs and long non-coding RNAs (lncRNAs) are among those that have gained attention recently in human diseases, including cancer, with the involvement of many more non-coding RNAs (ncRNAs) waiting to be discovered. ncRNAs are a group of ribonucleic acids transcribed from regions of the human genome, which do not become translated into proteins, despite having essential roles in cellular physiology. Deregulation of ncRNA expression and function has been observed in cancer pathogenesis. Recently, the roles of a group of ncRNA known as lncRNA have gained attention in cancer, with increasing reports of their oncogenic involvement. Female reproductive cancers remain a leading cause of death in the female population, accounting for almost a third of all female cancer deaths in 2016. The Wnt signalling pathway is one of the most important oncogenic signalling pathways which is hyperactivated in cancers, including female reproductive cancers. The extension of ncRNA research into their mechanistic roles in human cancers has also led to novel reported roles of ncRNAs in the Wnt pathway and Wnt-mediated oncogenesis. This review aims to provide a critical summary of the respective roles and cellular functions of Wnt-associated lncRNAs in female reproductive cancers and explores the potential of circulating cell-free lncRNAs as diagnostic markers and lncRNAs as therapeutic targets. LGR5, leucine-rich repeat-containing G-protein coupled receptor 5; lncRNA, long non-coding RNA; LRP, lipoprotein receptor-related protein; MALAT1, metastasis-associated lung adenocarcinoma transcript 1; miRNA, microRNA; NBAT1, neuroblastoma-associated transcript 1; ncRNA, non-coding RNAs; NEAT1, nuclear-enriched abundant transcript 1; NGS, next-generation sequencing; PCA3, prostate cancer antigen 3; PCDH10, protocadherin 10; PCP, Wnt/planar cell polarity; PCR2, polycomb repressive 2; Pinc, pregnancy-induced non-coding RNA; RNAi, RNA interference; shRNA, short hairpin RNAs; TCF, transcription factors T cell factor; UCA1, urothelial carcinoma-associated 1 LINKED ARTICLES

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Circ-8073 regulates CEP55 by sponging miR-449a to promote caprine endometrial epithelial cells proliferation via the PI3K/AKT/mTOR pathway

Liu

Zhang

Liu

et al. 2018

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

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Circular RNAs (circRNAs) are a large class of endogenous non-coding RNAs that function as regulators in various cells and tissues. Here, the function and mechanism of circRNA8073 (Circ-8073) on endometrial epithelial cells (EECs) and the development of endometrial receptivity were investigated in dairy goats. Circ-8073 could bind to and inhibit miR-449a activity. Circ-8073 binding to the target site of miR-449a had a negative feedback relationship. Centrosomal protein55 (CEP55) was a direct target gene of miR-449a, and Circ-8073 could increase the expression levels of CEP55 by sponging miR-449a in EECs in vitro. Circ-8073/miR-449a/CEP55 could promote EECs proliferation via the PI3K/AKT/mTOR pathway. In addition, CEP55 could regulate the expression levels of vascular endothelial growth factor (VEGF) and forkhead box M1 (FOXM1) in EECs, which contributed to the development of endometrial receptivity. These findings showed that Circ-8073 regulated CEP55 by sponging miR-449a to promote EEC proliferation via the PI3K/AKT/mTOR pathway, suggesting that it could function as a regulator in the development of endometrial receptivity in dairy goats.

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Identification of LncRNAs/mRNAs related to endometrium function regulated by Homeobox A10 in Ishikawa cells

Cited by 5 publications

References 42 publications

JPX and LINC00641 ncRNAs expression in prostate tissue: a case-control study

JPX and LINC00641 ncRNAs expression in prostate tissue: a case-control study

‘Lnc’‐ing Wnt in female reproductive cancers: therapeutic potential of long non‐coding RNAs in Wnt signalling

Circ-8073 regulates CEP55 by sponging miR-449a to promote caprine endometrial epithelial cells proliferation via the PI3K/AKT/mTOR pathway

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