Identification of Lineage-specific Transcriptional Factor–defined Molecular Subtypes in Small Cell Bladder Cancer

Feng, Mingxiao; Matoso, Andrés; Epstein, Gabriel; Fong, Megan; Park, Yong Hyun; Gabrielson, Andrew; Patel, Sunil; Czerniak, Bogdan; Compérat, Éva; Hoffman-Censits, Jeannie; Kates, Max; S, Kim; McConkey, David J.; Choi, Woonyoung

doi:10.1016/j.eururo.2023.05.023

Cited by 10 publications

(1 citation statement)

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“…Urothelial carcinoma is one of the most common cancers of the urinary system with an incidence of nearly 550,000 cases annually and is attributable to around 200,000 deaths annually ( 1 - 3 ). There are two types of bladder cancer (BC) based on the depth of tumor invasion: non-muscle invasive tumors, which account for approximately 70–80% of cases, and muscle-invasive tumors, which make up 20–30% of cases.…”

Section: Introductionmentioning

confidence: 99%

CCL5 promotes the proliferation and metastasis of bladder cancer via the JAK2/STAT3 signaling pathway

Shen,

Chen,

Chen

et al. 2023

Transl Androl Urol

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Background Non-muscle invasive bladder cancer (NMIBC) is one of the most common malignant tumors of the urinary system. There is an urgent need for further studies to elucidate the underlying mechanisms of bladder cancer (BC) progression. It has been observed that C-C chemokine ligand 5 (CCL5) and its receptor C-C chemokine receptor type 5 (CCR5) are expressed abnormally and activated in solid tumors and hematological malignancies, which is gaining increasing attention. However, the underlying mechanism of CCL5 in BC remains unclear. Methods The expression levels of CCL5 were analyzed by real-time polymerase chain reaction (RT-PCR) and western blot. Proliferation analysis of cells was carried out using Cell Counting Kit-8 (CCK-8). The assessment of the migration was conducted using a wound-healing assay. A Matrigel-coated transwell chamber was used to test cell invasiveness. A subcutaneous transplantation tumor model and tail vein injection pulmonary metastasis tumor model were used to evaluate the proliferation and metastasis of BC cell in vivo . Results This study showed that CCL5 promotes proliferative, migratory, and tumor-growing BC cells in vitro and tumor metastasizing BC cells in vivo . Moreover, we found that the tumor-promotive role of CCL5 is dependent on activation of the JAK2/STAT3 signaling pathway. Conclusions CCL5 may play an oncogenic role in BC and may also serve as a potential diagnostic and prognostic biomarker.

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Section: Introductionmentioning

confidence: 99%