“…In patients, 331 PCGs were up-regulated (based on logFC, the 12 most up-regulated genes were COL4A5, DSC2, CASS4, SLITRK5, LGALSL, CD5L, TPSB2, LOXL4, HBA1, MFAP3L, HBA2, and CANCB4) and 126 PCGs were down-regulated (the 12 most down-regulated genes were ARPP21, PAX5, EBF1, AKAP12, POU2AF1, RAG1, MME, AREG, CD79A, NEIL1, CD24, and LEF1). These differences were comparable to those published in earlier gene expression profiling studies (34)(35)(36)(37). For example, down-regulation of LEF1 significantly correlated with clinical outcome and might be promising for assessing prognosis in MDS (37).…”