Identification of KRAS mutation-associated gut microbiota in colorectal cancer and construction of predictive machine learning model
Zigui Huang,
Xiaoliang Huang,
Yili Huang
et al.
Abstract:Gut microbiota has demonstrated an increasingly important role in the onset and development of colorectal cancer (CRC). Nonetheless, the association between gut microbiota and KRAS mutation in CRC remains enigmatic. We conducted 16S rRNA sequencing on stool samples from 94 CRC patients and employed the linear discriminant analysis effect size algorithm to identify distinct gut microbiota between KRAS mutant and KRAS wild-type CRC patients. Transcriptome sequencing data from nine CRC patients were transformed i… Show more
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