Identification of key genes related to intramuscular fat deposition in Beijing-You chicken by mRNA and miRNA transcriptome analysis

Gai, Kai; Ge, Yu; Liu, Dapeng; Zhang, He; Cong, Bailin; Guo, Shihao; Liu, Yizheng; Xing, Kai; Qi, Xiaolong; Wang, Xiangguo; Xiao, Longfei; Long, Cheng; Guo, Yong; Chen, Li; Sheng, Xihui

doi:10.1016/j.psj.2023.103035

Cited by 4 publications

(3 citation statements)

References 43 publications

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“…Cui et al [ 55 ] explored the biochemical mechanisms underlying IMF deposition in chicken strains with increased fat content. Recently, a co-expression network analysis identified miR-29c-3p - PIK3R1 , miR-363-3p - PTEN , miR-6701-3p - PTEN , miR-449c/d-5p - TRAF6 , miR-6701-3p - BMPR1B , and miR-1563 - WWP1 as key miRNA and mRNA pairs controlling IMF accumulation [ 20 ] ( Table 1 ).…”

Section: Genetic Factors Influencing Meat Quality Traits In Chickenmentioning

confidence: 99%

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Unraveling the Genetic Foundations of Broiler Meat Quality: Advancements in Research and Their Impact

Lu,

Abdalla Gibril,

et al. 2024

Genes

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As societal progress elevates living standards, the focus on meat consumption has shifted from quantity to quality. In broiler production, optimizing meat quality has become paramount, prompting efforts to refine various meat attributes. Recent advancements in sequencing technologies have revealed the genome’s complexity, surpassing previous conceptions. Through experimentation, numerous genetic elements have been linked to crucial meat quality traits in broiler chickens. This review synthesizes the current understanding of genetic determinants associated with meat quality attributes in broilers. Researchers have unveiled the pivotal insights detailed herein by employing diverse genomic methodologies such as QTL-based investigations, candidate gene studies, single-nucleotide polymorphism screening, genome-wide association studies, and RNA sequencing. These studies have identified numerous genes involved in broiler meat quality traits, including meat lightness (COL1A2 and ACAA2), meat yellowness (BCMO1 and GDPD5), fiber diameter (myostatin and LncIRS1), meat pH (PRDX4), tenderness (CAPN1), and intramuscular fat content (miR-24-3p and ANXA6). Consequently, a comprehensive exploration of these genetic elements is imperative to devise novel molecular markers and potential targets, promising to revolutionize strategies for enhancing broiler meat quality.

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Section: Genetic Factors Influencing Meat Quality Traits In Chickenmentioning

confidence: 99%

“…However, integrating various analytical approaches can provide deeper insights into chicken meat quality development [ 20 , 58 ]. Research on chicken meat traits should encompass genetic exploration, muscle structure, physiological processes, feeding management, and advancements in nutritional technology.…”

Section: Future Perspectivesmentioning

confidence: 99%

Unraveling the Genetic Foundations of Broiler Meat Quality: Advancements in Research and Their Impact

Lu,

Abdalla Gibril,

et al. 2024

Genes

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“…Lin et al (2022) found that miRNA-24-3p dominated IMF deposition in chickens by promoting the proliferation and inhibiting the differentiation of intramuscular preadipocytes through blocking the expression of membrane-associated protein A6 (ANXA6) [71]. Gai et al (2023) showed that the IMF content of Beijing-You Chicken (BJY) at 1 d of age was significantly higher than that at later stages of birth, and miR-6701-3p-PTEN, miR-1563-WWP1, miR-6701-3p-BMPR1B, miR-29c-3p-PIK3R1, and miR-449c/d-5p-TRAF6 were identified as the key mRNA-miRNA pairs for regulating IMF deposition [72]. Zhu et al (2023) found that miR-128-3p inhibited chicken intramuscular adipocyte differentiation through down-regulation of farnesyl diphosphate synthase (FDPS) [73].…”

Section: Non-coding Rnas Controlling Imf Depositionmentioning

confidence: 99%

Genomic Insights into Molecular Regulation Mechanisms of Intramuscular Fat Deposition in Chicken

Cao,

Xing,

Guan

et al. 2023

Genes

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Intramuscular fat (IMF) plays an important role in the tenderness, water-holding capacity, and flavor of chicken meat, which directly affect meat quality. In recent years, regulatory mechanisms underlying IMF deposition and the development of effective molecular markers have been hot topics in poultry genetic breeding. Therefore, this review focuses on the current understanding of regulatory mechanisms underlying IMF deposition in chickens, which were identified by multiple genomic approaches, including genome-wide association studies, whole transcriptome sequencing, proteome sequencing, single-cell RNA sequencing (scRNA-seq), high-throughput chromosome conformation capture (HiC), DNA methylation sequencing, and m6A methylation sequencing. This review comprehensively and systematically describes genetic and epigenetic factors associated with IMF deposition, which provides a fundamental resource for biomarkers of IMF deposition and provides promising applications for genetic improvement of meat quality in chicken.

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Unraveling the genetic and epigenetic landscape governing intramuscular fat deposition in rabbits: Insights and implications

Ahamba,

Mary-Cynthia Ikele,

Kinkpe

et al. 2024

Food Chemistry: Molecular Sciences

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Identification of key genes related to intramuscular fat deposition in Beijing-You chicken by mRNA and miRNA transcriptome analysis

Cited by 4 publications

References 43 publications

Unraveling the Genetic Foundations of Broiler Meat Quality: Advancements in Research and Their Impact

Unraveling the Genetic Foundations of Broiler Meat Quality: Advancements in Research and Their Impact

Genomic Insights into Molecular Regulation Mechanisms of Intramuscular Fat Deposition in Chicken

Unraveling the genetic and epigenetic landscape governing intramuscular fat deposition in rabbits: Insights and implications

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