Identification of key genes and pathways associated with different immune statuses of hepatitis B virus infection

Jin, Jinglan; Xu, Hao; Wu, Ruihong; Gao, Na; Wu, Na; Li, Shibo; Niu, Junqi

doi:10.1111/jcmm.14616

Cited by 7 publications

(5 citation statements)

References 61 publications

(125 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…FcγRIIb is an inhibitory receptor, works as a regulation molecule of the immunosystem, and is vital for the progression of various autoimmune diseases and infectious diseases. In our previous study, we performed qRT-PCR assay to identify FcγRIIb mRNA expression in HBV sufferers [22]. The study showed that FcγRIIb expression was higher in the HBV carrier group in contrast to the CHB group.…”

Section: Discussionmentioning

confidence: 99%

Fc Gamma RIIb Expression Levels in Patients With Chronic Hepatitis B Virus Infection

Jin¹,

Liu²,

Xu³

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Background: Fc gamma receptor IIb (FcγRIIb), is an important inhibitory receptor which plays a vital role in regulating various immunoresponse processes and pathogenesis of many infectious disease. The purpose of our research is to show the FcγRIIb expression in serum and liver biopsy specimen of hepatitis B virus (HBV) suffers and explore its association with chronic HBV infection.Methods: ELISA assay was adopted to identify the serum FcγRIIb levels in 119 HBV suffers and 24 healthy controls. The immunohistochemical method was then employed to identify FcγRIIb expression in the biopsy specimens of patients with chronic hepatitis B (CHB). The integrated optical density (IOD) value was measured to represent FcγRIIb expression levels.Results: The serum FcγRIIb levels were decreased in CHB patients compared to controls (P < 0.001). FcγRIIb levels in CHB patient group were remarkably lower than in HBV carrier group (P< 0.001). In addition, the serum FcγRIIb levels were negatively associated with AST and ALT (r=-0.3936，P=0.0063; r=-0.3459，P =0.0097 respectively). The IOD values of FcγRIIb expression in moderate CHB and severity CHB group were significantly lower (P=0.006, P<0.001, respectively). The FcγRIIb level tended to be lower with the pathological changes of hepatitis. Further, the correlation analysis revealed FcγRIIb had negative correlations with AST and ALT (r=-0.688，P=0.0016; r=-0.686，P=0.0017 respectively) but positively associated with platelet counts (r=0.6464，P=0.0038).Conclusions: FcγRIIb levels are significantly related to chronic HBV infection and progression of CHB. The change of FcγRIIb may affect the progression of liver inflammation and fibrosis in CHB patients

show abstract

Section: Discussionmentioning

confidence: 99%

Fc Gamma RIIb Expression Levels in Patients With Chronic Hepatitis B Virus Infection

Jin¹,

Liu²,

Xu³

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…FcγRIIb is an inhibitory receptor that functions as a regulation molecule in the immune system and is vital in the progression of various autoimmune diseases and infectious diseases. In our previous study, we performed qRT-PCR assay to assess FcγRIIb mRNA expression in HBV infected patients [ 25 ]. The study showed that FcγRIIb expression was higher in the HBV carrier group than in the CHB group.…”

Section: Discussionmentioning

confidence: 99%

The association between Fc gamma RIIb expression levels and chronic hepatitis B virus infection progression

Jin

Liu

et al. 2021

BMC Infect Dis

Self Cite

View full text Add to dashboard Cite

Background Fc gamma receptor IIb (FcγRIIb) is an important inhibitory receptor that plays vital roles in regulating various immune response processes and the pathogenesis of many infectious diseases. The purpose of our research was to evaluate FcγRIIb expression in serum and liver biopsy specimens from hepatitis B virus (HBV)-infected patients and to explore the association of FcγRIIb with chronic HBV infection. Methods Enzyme-linked immunosorbent assay (ELISA) was adopted to measure the serum FcγRIIb levels in 119 HBV-infected patients and 24 healthy controls. An immunohistochemical method was then employed to identify FcγRIIb expression in biopsy specimens from patients with chronic hepatitis B (CHB). The integrated optical density (IOD) value was measured to represent FcγRIIb expression levels. Results Serum FcγRIIb levels were decreased in CHB patients compared to controls (P < 0.001). The FcγRIIb levels in the CHB patient group were remarkably lower than those in the HBV carrier group (P < 0.001). In addition, FcγRIIb levels were negatively associated with AST and ALT (r = −0.3936, P = 0.0063; r = −0.3459, P = 0.0097, respectively). The IOD values of FcγRIIb expression in the moderate and severe CHB groups were significantly lower than those in the control group (P = 0.006 and P < 0.001, respectively). The FcγRIIb level tended to be lower with pathological changes related to hepatitis. Furthermore, correlation analysis revealed that FcγRIIb had negative correlations with AST and ALT (r = −0.688, P = 0.0016; r = −0.686, P = 0.0017, respectively) but a positive association with the platelet count (r = 0.6464, P = 0.0038). Conclusions FcγRIIb levels are significantly related to chronic HBV infection and the progression of CHB. Changes in FcγRIIb may affect the progression of liver inflammation and fibrosis in CHB patients.

show abstract

“…IgG3 was also higher compared with that of HCs, but without significance. IgG serves a pivotal role in viral neutralization ( 49 ). Antigens can trigger B-cells directly, leading to a plethora of secondary signals that regulates cell differentiation and subsequent antibody production ( 50 , 51 ).…”

Section: Discussionmentioning

confidence: 99%

“…Antigens can trigger B-cells directly, leading to a plethora of secondary signals that regulates cell differentiation and subsequent antibody production ( 50 , 51 ). The induction of specific IgG1 and IgG3 antibodies is therefore more likely to achieve the clearance of HBV and HCV ( 49 ).…”

Section: Discussionmentioning

confidence: 99%

Levels of serum IgG subclasses in patients with liver disease: A retrospective study

et al. 2020

View full text Add to dashboard Cite

Viral and alcoholic liver disease, drug induced liver disease (DILD), primary biliary cirrhosis (PBC) and autoimmune hepatitis (AIH) are among the most common liver diseases observed in clinical practice. These diseases lack unique clinical characteristics at the beginning of pathogenesis, which renders specific diagnosis difficult. Immunoglobulin G (IgG) subclasses are the main isoform of antibodies that can be found in the serum that serve important protective roles in immunity. The present study aimed to investigate the serum IgG subclass distribution in patients with the five common liver diseases aforementioned. The present study retrospectively recorded and analyzed the serum IgG subclass levels of different patients, who were grouped according to their clinical diagnosis. Serum IgG subclass levels were measured using immunonephelometric assays. IgG3 levels were found to be significantly increased whereas IgG4 levels were significantly decreased in patients with PBC. In patients with AIH, IgG1 levels were significantly increased. By contrast, IgG1/IgG level ratios in patients with viral liver disease were significantly increased. No clear pattern in the distribution characteristics of IgG subclasses could be observed in cohorts with alcoholic liver disease and DILD in the present study. Additionally, model for end-stage liver disease scores regarding IgG1 in patients with AIH shared a synergistic relationship. Anti-mitochondrial antibody subtype M2 (AMA-M2) and IgG3 in patients with PBC demonstrated a synergistic relationship. These results suggested that IgG subclasses may be used as biomarkers to further the understanding of liver disease, which could allow for early diagnosis.

show abstract

Identification of key genes and pathways associated with different immune statuses of hepatitis B virus infection

Cited by 7 publications

References 61 publications

Fc Gamma RIIb Expression Levels in Patients With Chronic Hepatitis B Virus Infection

Fc Gamma RIIb Expression Levels in Patients With Chronic Hepatitis B Virus Infection

The association between Fc gamma RIIb expression levels and chronic hepatitis B virus infection progression

Levels of serum IgG subclasses in patients with liver disease: A retrospective study

Contact Info

Product

Resources

About