Identification of Key Genes and Signaling Pathways in Male Androgenetic Alopecia by Bioinformatics Analysis

Zhang, Mengzhi; Chen, Yujia; Guan, Lina; Li, Wen; Chen, Yunzhi

doi:10.1145/3403782.3403795

Proceedings of the Fourth International Conference on Biological Information and Biomedical Engineering 2020

DOI: 10.1145/3403782.3403795

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Identification of Key Genes and Signaling Pathways in Male Androgenetic Alopecia by Bioinformatics Analysis

Mengzhi Zhang

Yujia Chen

Lina Guan

et al.

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2022

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“…frontal and vertex regions) and nonbalding area (i.e. occipital region) of individuals with AGA, 10 , 11 including androgen metabolism, the Wnt/β‐catenin pathway, and redox state. 12 , 13 , 14 , 15 , 16 , 17 , 18 However, these studies only detected the mRNA alterations while the changes of other noncoding RNAs were neglected.…”

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confidence: 99%

Insights into male androgenetic alopecia using comparative transcriptome profiling: hypoxia-inducible factor-1 and Wnt/β-catenin signalling pathways

Liu

Tang

Huang

et al. 2022

British Journal of Dermatology

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BackgroundThe key pathophysiological changes in androgenetic alopecia (AGA) are limited to hair follicles (HFs) in frontal and vertex regions, sparing the occipital region. Objectives To identify biological differences among HF subpopulations. Methods Paired vertex and occipital HFs from 10 male donors with AGA were collected for RNA sequencing assay. Furthermore, HF and cell experiments were conducted on the identified key genes to reveal their roles in AGA. Results Transcriptome profiles revealed that 506 mRNAs, 55 microRNAs and 127 long noncoding RNAs were differentially expressed in the AGA vertex HFs. Pathway analysis of mRNAs and microRNAs revealed involvement of the hypoxiainducible factor (HIF)-1, Wnt/β-catenin, and focal adhesion pathways. Differential expression of HIF-1 prolyl hydroxylase enzymes (EGLN1, EGLN3) and Wnt/βcatenin pathway inhibitors (SERPINF1, SFRP2) was experimentally validated. In vitro studies revealed that reduction of EGLN1, EGLN3, SERPINF1 and SFRP2 stimulated proliferation of dermal papilla cells. Ex vivo HF studies showed that downregulation of EGLN1, EGLN3 and SERPINF1 promoted HF growth, postponed HF catagen transition, and prolonged the anagen stage, suggesting that these genes may be potentially utilized as therapeutic targets for AGA. Conclusions We characterized key transcriptome changes in male AGA HFs, and found that HIF-1 pathway-related genes (EGLN1, EGLN3) and Wnt pathway inhibitors (SERPINF1, SFRP2) may play important roles in AGA.What is already known about this topic?• Multiple differentially expressed genes and signalling pathways have been found between hair follicles (HFs) in the balding area (frontal and vertex regions) and nonbalding area (occipital region) of individuals with androgenetic alopecia (AGA). • A whole-transcriptome atlas of the vertex and occipital region is lacking.

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confidence: 99%

Insights into male androgenetic alopecia using comparative transcriptome profiling: hypoxia-inducible factor-1 and Wnt/β-catenin signalling pathways

Liu

Tang

Huang

et al. 2022

British Journal of Dermatology

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Identification of Key Genes and Signaling Pathways in Male Androgenetic Alopecia by Bioinformatics Analysis

Cited by 1 publication

References 30 publications

Insights into male androgenetic alopecia using comparative transcriptome profiling: hypoxia-inducible factor-1 and Wnt/β-catenin signalling pathways

Insights into male androgenetic alopecia using comparative transcriptome profiling: hypoxia-inducible factor-1 and Wnt/β-catenin signalling pathways

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