Identification of Kaposin (ORF K12) as a Human Herpesvirus 8 (Kaposi's Sarcoma Associated Herpesvirus) Oncogene.

Muralidhar, Sumitra; Pumfery, Anne; Hassani, Morad; Sadaie, M. Reza; Azumi, Norio; Brady, John; Medveczky, Peter G.; Rosenthal, Leonard J.

doi:10.1097/00042560-199804010-00077

Cited by 61 publications

(78 citation statements)

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“…For HHV-8, only five latently expressed genes have been identified. They include the latency-associated nuclear antigens (LANA), the v-cyclin, the v-FLIP, the kaposin, and the vIRF-2 or LANA-2 (Kedes et al, 1997b;Rainbow et al, 1997;Dittmer et al, 1998;Muralidhar et al, 1998;Sadler et al, 1999;Burysek and Pitha, 2001;Saveliev et al, 2002). How the expression of these genes plays a role in the maintenance of latency and the transformed phenotype still needs to be elucidated.…”

Section: Hhv-8 Latencymentioning

confidence: 99%

The role of Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 regulator of transcription activation (RTA) in control of gene expression

2003

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The mechanisms that control the replication state, latency versus lytic, of human herpesviruses have been under intense investigations. Here we summarize some of the recent findings that help define such mechanisms for Kaposi's sarcoma-associated herpesvirus/human herpesvirus type 8 (KSHV/HHV-8). For HHV-8, the viral regulator of transcription activation (RTA) is a key mediator of the switch from latency to lytic gene expression in infected cells. RTA is necessary and sufficient to drive HHV-8 lytic replication and the production of viral progeny. The RTA is an immediateearly gene product, it is the initial activator of expression of a multitude of viral and cellular genes that have been implicated in the replication of HHV-8 and pathogenesis of KS. Interactions of RTA with a number of viral promoters, and with a number of transcription factors or transcriptional co-activators are highlighted. Modulation of transactivation, through alternate RTA-protein, or RTA-promoter interactions, is hypothesisized to participate in the selective tissue tropism and differential pathogenesis observed in KS.

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Section: Hhv-8 Latencymentioning

confidence: 99%

The role of Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 regulator of transcription activation (RTA) in control of gene expression

2003

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“…The kaposin gene is expressed during latency but can also be induced on lytic replication (Muralidhar et al, 1998(Muralidhar et al, ,2000Sadler et al, 1999;Wang and Boshoff, 2005). This gene is most abundantly expressed during latency and has a complex translational pattern resulting in three different forms of the kaposin proteins, known as A, B, and C (Sadler et al, 1999).…”

Section: Viral Oncogenesismentioning

confidence: 99%

“…This gene is most abundantly expressed during latency and has a complex translational pattern resulting in three different forms of the kaposin proteins, known as A, B, and C (Sadler et al, 1999). Kaposin A is a type II membrane protein, and it was shown to have transforming activities and can transform cells in vitro; the transformed cells caused tumors in nude mice (Kliche et al, 2001;Muralidhar et al, 1998Muralidhar et al, ,2000. Its transforming activities were linked to its interaction with a guanine nucleotide exchange factor for ARF GTP ase known as cytokesin-1 and a domain known as the LXXLL motif on the protein seems to be important for transformation (Tomkowicz et al, 2005).…”

Section: Viral Oncogenesismentioning

confidence: 99%

The Viral Etiology of AIDS‐Associated Malignancies

Angeletti

Zhang

Wood

2008

HIV-1: Molecular Biology and Pathogenesis

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“…One of these transcripts encodes a protein, 'kaposin A', which has been reported to have transforming activity in rodent fibroblasts [107] and induces lymphocyte aggregation and adhesion possibly mediated through its direct interaction with cytohesin-1, a guanine nucleotide exchange factor for ARF GTPases and regulator of integrin-mediated cell adhesion [108,109]. Another encodes 'kaposin B', which binds to MK2, a cellular kinase in the p38 mitogenactivated kinase pathway central to the regulation of cytokine messenger RNAs containing AU-rich elements in their 3 coding regions [110].…”

Section: Kshv Latency and Latent Viral Genes In Ksmentioning

confidence: 99%

The pleiotropic effects of Kaposi's sarcoma herpesvirus

Schulz

2005

The Journal of Pathology

156

143

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Kaposi's sarcoma herpesvirus (KSHV), or human herpesvirus 8 (HHV8), is an essential factor in the pathogenesis of Kaposi's sarcoma (KS), multicentric Castleman's disease (MCD), and primary effusion lymphoma (PEL). Case reports suggest an occasional involvement in bone marrow hypoplasia and haemophagocytic syndrome, but other disease associations are unconfirmed or controversial. KSHV-associated disease is of particular importance in immunosuppressed individuals, in particular in patients with HIV infection and transplant recipients. KSHV establishes a latent infection in the majority of infected cells in KS, MCD, and PEL, but lytic replication occurs in a small fraction of infected cells. Viral proteins expressed during both the latent and the lytic phase of the viral life cycle contribute to the pathogenesis of KSHV-associated diseases.

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Identification of Kaposin (ORF K12) as a Human Herpesvirus 8 (Kaposi's Sarcoma Associated Herpesvirus) Oncogene.

Cited by 61 publications

References 0 publications

The role of Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 regulator of transcription activation (RTA) in control of gene expression

The role of Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 regulator of transcription activation (RTA) in control of gene expression

The Viral Etiology of AIDS‐Associated Malignancies

The pleiotropic effects of Kaposi's sarcoma herpesvirus

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