Identification of Isthmin‐1 in common carp (Cyprinus carpio L.) and the effects on glucose metabolism in vivo and in vitro
Leya Qu,
Liping Yang,
Yiran Wang
et al.
Abstract:Isthmin‐1 (Ism1) plays roles in glucose uptake in mammals as an adipokine. To investigate its role in the glucose metabolism of common carp (Cyprinus carpio. L), the Ism1 sequence was cloned, and its expression and distribution in tissues were detected. In addition, we prepared and purified the recombinant Ism1 protein using the E. coli expression system and assessed changes in the expression of key genes related to glucose metabolism through both in vivo injection experiments and primary hepatocyte experiment… Show more
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