Abstract:Single-cell RNA sequencing is a powerful tool to explore cancer heterogeneity. However, the expression of lncRNAs in single cells is still to be studied extensively and methods to deal with the sparsity of this type of data are lacking. Here, we propose a topic modeling approach to investigate the transcriptional heterogeneity of luminal and triple negative breast cancer cells using patient-derived xenograft models of acquired resistance to chemotherapy and targeted therapy.
We show that using an integrative … Show more
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