Identification of Inhibitors against Botulinum Neurotoxins: 8-Hydroxyquinolines Hold Promise

Abstract

Botulinum neurotoxins (BoNTs) are the most toxic category A biological warfare agents. There is no therapeutics available for BoNT intoxication yet, necessitating the development of a medical countermeasure against these neurotoxins. The discovery of small molecule-based drugs has revolutionized in the last two decades resulting in the identification of several small molecule inhibitors of BoNTs. However, none progressed to clinical trials. 8-Hydroxyquinolines scaffold-based molecules are important ‘privileged structures’ that can be exploited as inhibitors of a diverse range of targets. In this review, our study of recent reports suggests the development of 8-hydroxyquinoline derived molecules as a potential drug may be on the horizon.

A pH-Sensitive Lignin-Based Material for Sustained Release of 8-Hydroxyquinoline

“…For example, Crespy and coworkers [23] prepared pH-sensitive polymer conjugates from 8HQ, ethyl acrylate, and 2-mercaptoethanol, which could well be utilized in the corrosion protection of metal. Additionally, it has a broad prospect in pharmaceutical engineering [24][25][26][27][28][29][30]. Kljun et al [25] demonstrated the anticancer potential of organ ruthenium complexes of 8HQ.…”

“…Kljun et al [25] demonstrated the anticancer potential of organ ruthenium complexes of 8HQ. Chauhan et al [26] prepared a therapeutic agent for botulinum neurotoxins from 8HQ. Buchler et al [27] optimized the inhibitory effect of 8HQ inhibitors on catechol O-methyltransferase.…”