Identification of Important Invasion-Related Genes in Non-functional Pituitary Adenomas

Joshi, Harish; Vastrad, Basavaraj; Vastrad, Chanabasayya

doi:10.1007/s12031-019-01318-8

Cited by 9 publications

(8 citation statements)

References 142 publications

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“…The data showed that invasive tumors preferentially upregulate genes releted to organ morphogenesis, extracellular matrix, and hormone activity, and downregulate those mainly associated with leukocyte chemotaxis, dendrites, and RAGE receptor binding. ESR1, SOX2, TTN, GFAP, WIF1, TTR, XIST, SPAG5, PPBP, AR, IL1R2, and HIST1H1C were found as the top hub genes in the upregulated and downregulated networks [172]. Immunohistochemical validation of the expression of putative biomarkers of invasion previously suggested by gene expression profiling studies is still limited.…”

Section: Pathological and Molecular Considerationsmentioning

confidence: 96%

“…Specifically, they found six genes which appeared to be novel molecular biomarkers for invasion, which may be useful for diagnostic purposes: claudin 7 (CLDN7), contactin associated protein-like 2 (CNTNAP2), integrin, α6 (ITGA6), junctional adhesion molecule 3 (JAM3), protein tyrosine phosphatase, receptor type, C (PTPRC), and cadherin-associated protein α1 [171]. Recently, Joshi et al [172] performed molecular screening of genes that are differentially expressed between invasive non-functioning adenoma samples and normal pituitary gland followed by pathway and ontology enrichment analyses. The data showed that invasive tumors preferentially upregulate genes releted to organ morphogenesis, extracellular matrix, and hormone activity, and downregulate those mainly associated with leukocyte chemotaxis, dendrites, and RAGE receptor binding.…”

Section: Pathological and Molecular Considerationsmentioning

confidence: 99%

See 1 more Smart Citation

Pituitary Adenomas and Invasiveness from Anatomo-Surgical, Radiological, and Histological Perspectives: A Systematic Literature Review

Serioli

Doglietto

Fiorindi

et al. 2019

Cancers

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Invasiveness in pituitary adenomas has been defined and investigated from multiple perspectives, with varying results when its predictive value is considered. A systematic literature review, following PRISMA guidelines, was performed, searching PubMed and Scopus databases with terms that included molecular markers, histological, radiological, anatomical and surgical data on invasiveness of pituitary adenomas. The results showed that differing views are still present for anatomical aspects of the sellar region that are relevant to the concept of invasiveness; radiological and histological diagnoses are still limited, but might improve in the future, especially if they are related to surgical findings, which have become more accurate thanks to the introduction of the endoscope. The aim is to achieve a correct distinction between truly invasive pituitary adenomas from those that, in contrast, present with extension in the parasellar area through natural pathways. At present, diagnosis of invasiveness should be based on a comprehensive analysis of radiological, intra-operative and histological findings.

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Section: Pathological and Molecular Considerationsmentioning

confidence: 96%

Section: Pathological and Molecular Considerationsmentioning

confidence: 99%

Pituitary Adenomas and Invasiveness from Anatomo-Surgical, Radiological, and Histological Perspectives: A Systematic Literature Review

Serioli

Doglietto

Fiorindi

et al. 2019

Cancers

View full text Add to dashboard Cite

show abstract

“…Moreover, previous studies identified a perturbation in some signaling pathways that can make NFPAs prone to invasiveness. The main reported pathways include the “WNT signaling pathway” 12 , “local suppression of the immune response pathway”, “TGF-β signaling” 14 , “PI3K-Akt signaling pathway” and “chemokine signaling pathway” 15 . However, notwithstanding that the molecular markers and pathways associated with NFPA invasiveness are extensively studied, much remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Nkx3-1 and Fech genes might be switch genes involved in pituitary non-functioning adenoma invasiveness

Khayer

Jalessi

Jahanbakhshi

et al. 2021

Sci Rep

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Non-functioning pituitary adenomas (NFPAs) are typical pituitary macroadenomas in adults associated with increased mortality and morbidity. Although pituitary adenomas are commonly considered slow-growing benign brain tumors, numerous of them possess an invasive nature. Such tumors destroy sella turcica and invade the adjacent tissues such as the cavernous sinus and sphenoid sinus. In these cases, the most critical obstacle for complete surgical removal is the high risk of damaging adjacent vital structures. Therefore, the development of novel therapeutic strategies for either early diagnosis through biomarkers or medical therapies to reduce the recurrence rate of NFPAs is imperative. Identification of gene interactions has paved the way for decoding complex molecular mechanisms, including disease-related pathways, and identifying the most momentous genes involved in a specific disease. Currently, our knowledge of the invasion of the pituitary adenoma at the molecular level is not sufficient. The current study aimed to identify critical biomarkers and biological pathways associated with invasiveness in the NFPAs using a three-way interaction model for the first time. In the current study, the Liquid association method was applied to capture the statistically significant triplets involved in NFPAs invasiveness. Subsequently, Random Forest analysis was applied to select the most important switch genes. Finally, gene set enrichment (GSE) and gene regulatory network (GRN) analyses were applied to trace the biological relevance of the statistically significant triplets. The results of this study suggest that “mRNA processing” and “spindle organization” biological processes are important in NFAPs invasiveness. Specifically, our results suggest Nkx3-1 and Fech as two switch genes in NFAPs invasiveness that may be potential biomarkers or target genes in this pathology.

show abstract

“…Moreover, previous studies identi ed a perturbation in some signaling pathways that can make NFPAs prone to invasiveness. The main reported pathways include the "WNT signaling pathway" [12], "local suppression of the immune response pathway", "TGF-β signaling" [14], "PI3K-Akt signaling pathway" and "chemokine signaling pathway" [15]. However, notwithstanding that the molecular markers and pathways associated with NFPA invasiveness are extensively studied, much remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Nkx3-1 and Fech Genes Might be Switch Genes Involved in Pituitary Non-Functioning Adenoma Invasiveness

Khayer

Jalessi

Jahanbakhshi

et al. 2021

Preprint

View full text Add to dashboard Cite

Non-functioning pituitary adenomas (NFPAs) are typical pituitary macroadenomas in adults that are associated with increased mortality and morbidity. Although pituitary adenomas are commonly considered slow-growing benign brain tumors, numerous of them possess an invasive nature. Such tumors destroy sella turcica and invade the adjacent tissues such as the cavernous sinus and sphenoid sinus. The most critical obstacle for complete surgical removal in these cases is the high risk of damaging adjacent vital structures. Therefore, the development of novel therapeutic strategies for either early diagnosis through biomarkers or medical therapies to reduce the recurrence rate of NFPAs is imperative. Identification of gene interactions has paved the way for decoding complex molecular mechanisms, including disease-related pathways, and identifying the most momentous genes involved in a specific disease. Currently, our knowledge of the invasion of the pituitary adenoma at the molecular level is not sufficient. The current study aimed to identify critical biomarkers and biological pathways associated with invasiveness in the NFPAs using a three-way interaction model for the first time. In the current study, the Liquid association method was applied to capture the statistically significant triplets that are involved in NFPAs invasiveness. Subsequently, Random Forest analysis was applied to select the most important switch genes. Finally, gene set enrichment (GSE) and gene regulatory network (GRN) analyses were applied to trace the biological relevance of the statistically significant triplets. The results of this study suggest that “mRNA processing” and “spindle organization” biological processes are important in NFAPs invasiveness. Specifically, our results suggest Nkx3-1 and Fech as two switch genes in NFAPs invasiveness that may be a potential biomarkers or target genes, in this pathology.

show abstract

Identification of Important Invasion-Related Genes in Non-functional Pituitary Adenomas

Cited by 9 publications

References 142 publications

Pituitary Adenomas and Invasiveness from Anatomo-Surgical, Radiological, and Histological Perspectives: A Systematic Literature Review

Pituitary Adenomas and Invasiveness from Anatomo-Surgical, Radiological, and Histological Perspectives: A Systematic Literature Review

Nkx3-1 and Fech genes might be switch genes involved in pituitary non-functioning adenoma invasiveness

Nkx3-1 and Fech Genes Might be Switch Genes Involved in Pituitary Non-Functioning Adenoma Invasiveness

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