Identification of Immune-Related lncRNA Biomarkers Associated With Prognosis In LUAD

Abstract

Background: Long non-coding RNAs (lncRNAs) are involved in regulation of immune response and could serve as biomarkers for tumors. Methods: WGCNA were used to construct an immune-related gene interaction network and elucidated possible functions of the lncRNAs by gene enrichment analyses. 6 lncRNAs were selected and used to construct an immune-related lncRNAs risk score (ILRS) classifier. Results: Patients with high and low ILRS showed significant differences in microenvironment and immune cell infiltration type. Furthermore, enrichment analyses showed that these lncRNAs regulated immune-related pathways. Finally, four clusters derived from LUAD patients showed a significant correlation with overall survival of patients. Conclusions: This work provide new insights for subsequent development of clinical strategies against the disease.