Identification of imaging features that determine quality and repeatability of retinal capillary plexus density measurements in OCT angiography

Fenner, Beau J.; Tan, Gavin Siew Wei; Tan, Anna; Yeo, Ian; Wong, Tien Yin; Cheung, Chui Ming Gemmy

doi:10.1136/bjophthalmol-2017-310700

Cited by 79 publications

(66 citation statements)

References 32 publications

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“…Our results are consistent with literature reports on the OCTA metrics for macular superficial capillary 29. The high repeatability suggests that the moderate interocular correlation of fractal dimension and VDI and poor interocular correlation of the parafoveal vessel density are not due to variation in measurements.…”

Section: Discussionsupporting

confidence: 92%

Repeatability, interocular correlation and agreement of quantitative swept-source optical coherence tomography angiography macular metrics in healthy subjects

et al. 2018

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Section: Discussionsupporting

confidence: 92%

Repeatability, interocular correlation and agreement of quantitative swept-source optical coherence tomography angiography macular metrics in healthy subjects

et al. 2018

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“…In a similar study to ours, Oh et al assessed in 261 Asian individuals, the relationship between retinal and choroidal VD, and concluded that CC VD varies with retinal VD (SCP VD vs CC VD R = .278, DCP VD vs CC VD R = .273; both P < .001) rather than with choroid structure (VD vs subfoveal choroidal thickness R = .100; P = .109). 34,35 These variation sources will need to be addressed before OCTA can be used in routine clinical practice for the diagnosis and management of retinal diseases. As stated by Rabiolo et al, it should be highlighted that absolute VD values calculated with different algorithms are not directly interchangeable, so studies adopting VD as an outcome measure should not rely on external normative databases.…”

Section: Discussionmentioning

confidence: 99%

“…16,17 Also, numerous other variables such as measurement and analysis methods, motion artefacts or diurnal variations may affect the accuracy and repeatability of VD measurements. 34,35 These variation sources will need to be addressed before OCTA can be used in routine clinical practice for the diagnosis and management of retinal diseases.…”

Section: Discussionmentioning

confidence: 99%

Normative database and determinants of macular vessel density measured by optical coherence tomography angiography

Fernández‐Vigo

Kudsieh²,

Shi

et al. 2019

Clinical Exper Ophthalmology

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Importance To provide a normative vessel density (VD) database for the macula through swept‐source optical coherence tomography angiography (OCTA) and to assess the main determinants of this measurement. Background In contrast with dye angiography, the recently introduced OCTA technique allows for the non‐invasive measurement of retinal and choroidal VD metrics. Design Cross‐sectional study. Participants The right eyes of 346 healthy subjects were studied. In 105 subjects both eyes were imaged. Methods Foveal and parafoveal macular VD measurements were obtained in the retinal superficial capillary plexus (SCP), deep capillary plexus (DCP), and in the choriocapillaris (CC) layer. Also recorded were age, sex, axial length (AL), foveal and choroidal thickness (CT). Main Outcome Measures Normative database and determinants of macular VD measured by OCTA. Results Mean participant age was 38.3 ± 20.1 years (mean ± SD) (range 5‐83). Foveal VDs in the different plexuses were: SCP 22.1% ± 5.0% (7.3‐35.1), DCP 19.9% ± 6.3% (6.9‐51.2) and CC: 52.8% ± 4.3% (40.2‐62.1). Parafoveal VDs ranged from 45.4% ± 3.7% to 51.8% ± 4.6%. Positive correlation was observed between foveal VD and foveal thickness (R = .327), as well as between parafoveal DCP VD and CT (R = .250;P ≤ .006), while correlation with age was negative in the SCP and CC (R = −.283;P < .001). No associations were detected between macular VD and sex or AL (P ≥ .05). Conclusion and Relevance Macular VD showed wide individual variation, was positively correlated with foveal thickness and with CT, negatively correlated with age, and showed no correlation with AL or sex.

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“…Fenner et al. () reported that the visibility of the fine vasculature of the retinal capillary plexus, motion artefacts and the TopQ score, which represents similar parameters to SS, could be used to assess the quality of OCTA scans to ensure reliability. As we excluded images with any artefacts, both studies are consistent in the importance of SS in terms of OCTA reliability.…”

Section: Discussionmentioning

confidence: 99%

“…, ; Fenner et al. ). These OCTA parameters also showed reasonable repeatability in patients with various ophthalmic diseases in other studies (Lee et al.…”

Section: Introductionmentioning

confidence: 99%

Long‐term repeatability of optical coherence tomography angiography parameters in healthy eyes

Lee

Nam

Lim

et al. 2019

Acta Ophthalmologica

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Purpose: To determine the long-term repeatability of optical coherence tomography angiography (OCTA) parameters in normal eyes. Methods: We prospectively enrolled 104 normal eyes. Participants were divided into three groups based on differences in the signal strength (SS) of OCTA scans obtained at two visits at least 6 months apart: group 1, SS difference = 2; group 2, 1; group 3, 0. We measured a foveal centred scan area of 3 3 3 mm pattern. All measurements were performed twice at 5-min intervals at the initial visit. The second measurements were performed at least 6 months later. Results: In short-term vessel density (VD) repeatability, the coefficient of variation (CV) ranged from 3.89% to 8.10% and the intraclass correlation coefficient (ICC) ranged from 0.785 to 0.941. In terms of long-term repeatability, the CV was 5.39-12.62% and the ICC was 0.598-0.867. In group 1, the ICCs of the inner and full VDs were 0.194 and 0.221, respectively. In groups 2 and 3, the ICCs of the inner and full VDs were 0.611 and 0.603, and 0.763 and 0.765, respectively. The central VDs of all groups had high CV besides high ICC.Conclusions: Optical coherence tomography angiography parameters showed good short-term and reasonable long-term repeatability in normal individuals. The differences in SSs between measurements affected such repeatability, so physicians should query the reliability of OCTA parameters when the differences in SS are 2 or more even when the SS is high.

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Identification of imaging features that determine quality and repeatability of retinal capillary plexus density measurements in OCT angiography

Abstract: Our study identified the imaging parameters that determined the repeatability of quantitative retinal vessel density measurements. These findings have implications in determining if OCT-A images can be used to accurately evaluate serial changes in retinal vessel density.

Cited by 79 publications

References 32 publications

Repeatability, interocular correlation and agreement of quantitative swept-source optical coherence tomography angiography macular metrics in healthy subjects

Repeatability, interocular correlation and agreement of quantitative swept-source optical coherence tomography angiography macular metrics in healthy subjects

Normative database and determinants of macular vessel density measured by optical coherence tomography angiography

Long‐term repeatability of optical coherence tomography angiography parameters in healthy eyes

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