Identification of<i>Streptococcus pyogenes</i>on Tonsillar Epithelium during Infection

Stenfors, Lars‐Eric; Fredriksen, Fredrik; Räisänen, Simo; Myklebust, R.

doi:10.3109/00016489709124125

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…Whereas the presence of pili in Gram-negative bacteria was reported early (Brinton, 1965;Costerton et al, 1981;Jones & Isaacson, 1983;Heckels, 1989;Orndorff & Bloch, 1990;Hultgren et al, 1991), for a long time their presence in Gram-positive bacteria were considered dubious just because it was against the current 'dogma'. Proving once more such a tenet is foreign to the world of science (Ray, 1991;Johnson, 1999;Bussard, 2005), these structures are now well recognized in these bacteria (Hayashi et al, 1985;Fujita et al, 1992;Stenfors et al, 1997;Rakotoarivonina et al, 2002;Ton-That & Schneewind, 2003Desvaux et al, 2006a). However, in Gram-positive bacterial species the involvement of FPE in the formation of proper Type 4 pili has never been investigated and, except for LPXTG-pilin polymerization via sortase , no mechanism for pili formation is yet understood.…”

Section: Discussionmentioning

confidence: 99%

The protein secretion systems inListeria: inside out bacterial virulence

2006

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Listeria monocytogenes, the etiologic agent of listeriosis, remains a serious public health concern with its frequent occurrence in food coupled with a high mortality rate. The capacity of a bacterium to secrete proteins to or beyond the bacterial cell surface is of crucial importance in the understanding of biofilm formation and bacterial pathogenesis to further develop defensive strategies. Recent findings in protein secretion in Listeria together with the availability of complete genome sequences of several pathogenic L. monocytogenes strains, as well as nonpathogenic Listeria innocua Clip11262, prompted us to summarize the listerial protein secretion systems. Protein secretion would rely essentially on the Sec (Secretion) pathway. The twin-arginine translocation pathway seems encoded in all but one sequenced Listeria. In addition, a functional flagella export apparatus, a fimbrilin-protein exporter, some holins and a WXG100 secretion system are encoded in listerial genomes. This critical review brings new insights into the physiology and virulence of Listeria species.

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