Identification of hypoxia- and immune- based prognostic signature and validation of TFRC as a potential biomarker and therapeutic target in bladder cancer
Runhua Tang,
Haoran Wang,
Jianyong Liu
et al.
Abstract:Background
Bladder cancer is a common malignancy of the urinary system, and the survival rate and recurrence rate of patients with muscular aggressive (MIBC) bladder cancer are not ideal. Hypoxia is a pathological process in which cells acquire special characteristics to adapt to anoxic environment, which can directly affect the proliferation, invasion and immune response of bladder cancer cells. Understanding the exact effects of hypoxia and immune-related genes in BLCA is helpful for early assessment of the … Show more
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