Identification of hydrocarbon sulfonates as previously overlooked transthyretin ligands in the environment
Yufeng Gong,
Jianxian Sun,
Holly Barrett
et al.
Abstract:Incidences of thyroid disease, which has long been hypothesized to be partially caused by exposure to thyroid hormone disrupting chemicals (TDCs), have rapidly increased in recent years. However, only ~1% of the binding activity of human transthyretin (hTTR), an important thyroid hormone transporter protein, can be explained by known TDCs. In this study, we aimed to identify the major hTTR ligands in Canadian indoor dust and sewage sludge by employing protein-guided nontargeted analysis. hTTR binding activitie… Show more
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