Identification of human T-cell lymphotropic virus infection in a semi-isolated Afro-Brazilian quilombo located in the Marajó Island (Pará, Brazil)

Vallinoto, Antônio Carlos Rosário; Pontes, Gemilson Soares; Muto, Nilton Akio; Lopes, Ivina Giselle Lima; Machado, Luiz Fernando Almeida; Azevedo, Vânia Nakauth; Carvalhaes, Fernanda Andreza de Pinho Lott; Santos, Sidney Emanuel Batista dos; Guerreiro, João Farias; Ishak, Marluísa de Oliveira Guimarães; Ishak, Ricardo

doi:10.1590/s0074-02762006000100020

Cited by 27 publications

(34 citation statements)

References 10 publications

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“…� prevalência global da infecção pelo HTLV�1 neste estudo foi concordante com as observadas em doadores de sangue na Região Centro�Oeste 4 e em remanescentes de quilombos no Pará (1,1%; IC 95%: 0,3�3,6) 22 . Por outro lado, foi inferior à encontrada na população em geral de Salvador, Bahia (1,8%; IC 95%: 1,1�2,5) 8 , mas superior às verificadas em gestantes em Goiás (0,1%; IC 95%: 0,1�0,2) e Mato Grosso do Sul (0,1%; IC 95%: 0,1�0,2) 7 18 .…”

Section: Discussionunclassified

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Prevalência da infecção pelo HTLV-1, em remanescentes de quilombos no Brasil Central

Nascimento

Carneiro

Teles

et al. 2009

Rev. Soc. Bras. Med. Trop.

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Recebido para publicação em 06�08�2009 �ceito em 27�10�2009 � infecção pelo vírus linfotrópico de células T humanas 1 (HTLV�1) está associada com desenvolvimento de doenças graves como a leucemia�linfoma de células T do adulto (�TL) e mielopatia associada ao HTLV�1�paraparesia espástica tropical (H�M�TSP), além de síndromes inflamatórias e complicações infecciosas 24 ABSTRACTThis study aimed to determine the prevalence of HTLV�1 infection among remnant black quilombo communities in Central Brazil. � total of 1,837 individuals were evaluated, among whom nine were HTLV�1�2 seropositive according to ELIS�. �ll of them were positive for HTLV�1 by means of Western blot and�or PCR, thus resulting in a prevalence of 0.5% (95% CI: 0.2�1.0). The HTLV�1 infected individuals ranged in age from 11 to 82 years. The majority of them were females. Regarding risk characteristics, histories of breastfeeding, blood transfusion, multiple sexual partners and sexually transmitted diseases were reported by these individuals. The findings from this study indicate the importance of identifying HTLV�1 infected individuals, as a strategy for infection control and prevention in these remnant quilombos.Key-words: Human T�cell lymphotropic virus 1. Remnant quilombo. Central Brazil. Prevalence.observadas em algumas regiões como o sudoeste do Japão, Melanésia, África equatorial, Caribe e �mérica do Sul 20 . O Brasil é o país com maior número absoluto de indivíduos infectados por HTLV�1, possuindo cerca de dois milhões de portadores 3 . Essa infecção é endêmica em Salvador, Bahia, onde uma prevalência de 1,8% foi encontrada 8 . Segundo �lcântara e cols 1 , a introdução do HTLV�1 nesse estado ocorreu com o tráfico de escravos africanos. Estudo sobre HTLV�1�2, realizado em doadores de sangue nas capitais dos Estados brasileiros e Distrito Federal, obteve soroprevalência de 0,1% a 1%, sendo superior nas Regiões �orte e �ordeste, e inferior no sul do Brasil. �a Região Centro�Oeste, a prevalência verificada nessa população variou de 0,2% a 0,7% 4 . Em gestantes, uma prevalência de 0,1% foi observada para o HTLV�1 em Mato Grosso do Sul e Goiás 7 18 , e de 0,2% para HTLV�1�2 em Mato Grosso 25 . �s comunidades remanescentes de quilombos semi�isoladas no Brasil Central foram fundadas por africanos escravizados, que fugiram para locais de difícil acesso, e instituíram sociedades alternativas conhecidas como quilombos 21 . Considerando a possível origem africana do HTLV�1 e a escassez de estudos

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Section: Discussionunclassified

“…Considerando a possível origem africana do HTLV�1 e a escassez de estudos epidemiológicos para esse vírus nessas comunidades 22 , bem como a inexistência de dados sobre essa infecção em remanescentes de quilombos no Brasil Central, o presente estudo teve como objetivo estimar a prevalência da infecção pelo HTLV�1 nessa população. 10 23 .…”

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Prevalência da infecção pelo HTLV-1, em remanescentes de quilombos no Brasil Central

Nascimento

Carneiro

Teles

et al. 2009

Rev. Soc. Bras. Med. Trop.

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“…3 However, little is known about the epidemiological status of this infection in Afro-Brazilian isolated communities. 4 In this study, the prevalence of HTLV-1 infection in the Furnas da Boa Sorte, an isolated Afro-Brazilian slave-descendant community was determined. The community's 150 inhabitants live in very poor conditions in remote settlements on slopes and in valleys, called Furnas, in the North-Central region of the State of Mato Grosso do Sul, Central Brazil.…”

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confidence: 99%

“…2), the determinant of Brazilian HTLV-1 epidemic. 4,7 The LTR sequences from the present study are in GenBank (GQ443748-GQ443757).…”

mentioning

confidence: 99%

HTLV-1 intrafamilial transmission through three generations in an isolated Afro-Brazilian community

Martins¹,

Nascimento²,

Carneiro³

et al. 2010

Journal of Clinical Virology

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“…[1][2][3] The HTLV-1 infection is endemic in Japan and several countries in South America, Caribbean and Africa. 2,[4][5][6][7] The transmission pathways of HTLV-1 infection include vertical, parenteral and sexual transmission. 2,7 Risk factors associated with HTLV-1 infection include: hemotransfusion, low socioeconomic status, low education level, high-risk sexual behavior, anal sex, fi rst sexual relationship before 18 year-old and having more than 3 sexual partners in life.…”

Section: Introductionmentioning

confidence: 99%

Endocrine and metabolic disorders in HTLV-1 infected patients

Alves¹,

Dourado²

2010

Braz J Infect Dis

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Human T-cell leukemia virus type 1 (HTLV-1) infection is endemic in Japan and several countries in South America, Caribbean and Africa. Endocrine and metabolic disorders have been variably reported to be associated with human T-cell leukemia virus type 1 (HTLV-1) infection. Therefore, the aim of this article was to critically evaluate the current knowledge of the endocrine and metabolic disorders associated with HTLV-1 infection. The literature search used PubMed, Web of Science, and LILACS databases in the past 10 years, utilizing, in various combinations, the following keywords: HTLV-1, adult T-cell leukemia, diabetes mellitus, GLUT-1, osteoporosis, hypercalcemia, autoimmune thyroid disorders, diabetes insipidus, inappropriate antidiuretic hormone secretion; pseudohypoparathyroidism; pseudopseudohypoparathyroidism. The proven endocrine manifestations of the HTLV-1 infection are calcium disorders which occur in some patients with acute HTLV-1/Adult T-cell leukemia/lymphoma. The few reports about thyroid, parathyroid, antidiuretic hormone and diabetes mellitus are insuffi cient to prove a causal association with HTLV-1 infection. The evidence for an association between endocrine disorders and HTLV-1 infection in general, and in asymptomatic patients is lacking. Given all these uncertainties, the endocrine expression of the HTLV-1 infection composes a promising research line for understanding the pathophysiology of this infection.

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Identification of human T-cell lymphotropic virus infection in a semi-isolated Afro-Brazilian quilombo located in the Marajó Island (Pará, Brazil)

Abstract: Antibodies to human T-cell lymphotropic virus-1 and 2 (HTLV-1

Cited by 27 publications

References 10 publications

Prevalência da infecção pelo HTLV-1, em remanescentes de quilombos no Brasil Central

Prevalência da infecção pelo HTLV-1, em remanescentes de quilombos no Brasil Central

HTLV-1 intrafamilial transmission through three generations in an isolated Afro-Brazilian community

Endocrine and metabolic disorders in HTLV-1 infected patients

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