Identification of human leukocyte antigen in precancerous and cancerous cervical lesions from Ecuadorian women

Mora, María José; Bayas-Rea, Rosa de Los Ángeles; Mejía, Lorena; Cruz, Cecília Beatriz Bittencourt Viana; Guerra, Sara; Calle, Pamela; Sandoval, Diana Muñoz; Galarza, Juan Miguel; Mena, Sonia Zapata

doi:10.1016/j.meegid.2022.105365

Cited by 2 publications

(1 citation statement)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Identification of HPV genotypes and related risk factors in each population can affect the policies of this virus. Also, it should play a role in the screening of genotypes with high sensitivity to identify people infected with the virus and to diagnose intraepithelial neoplasia in infected people [18][19][20].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the prevalent genotypes of human papillomavirus in the population of women in Golestan province in the northeastern of Iran

Vosoo,

Sarli,

Yousefi

et al. 2023

Cell. Mol. Biomed. Rep.

View full text Add to dashboard Cite

Human papillomavirus (HPV) is a viral infection that usually causes growths on mucous membranes or skin (warts). It has been confirmed that there are more than 100 types of human papillomavirus (HPV). Some types of HPV infections cause warts, and some of them may cause different types of cancer. One of the most common ways of transmitting the HPV virus is unprotected sex, and this virus is the leading cause of cancers of the urinary and genital tracts. Cervical cancer is the fourth cause of cancer death in women, and more than 90% are associated with persistent infection by one of the most dangerous types of the virus. This research aimed to determine the genotypes of the HPV virus in DNA extracted from people suspected of being infected with HPV. In this cross-sectional epidemiological study, 225 cytology samples have been obtained from people suspected of being infected with the HPV virus, who had been referred to the Pardis laboratory of medical genetics in the Gonbad for diagnosis from 2022 to 2023. DNA extraction was done by CEDBIO kit and the determination of HPV virus genotypes was done by a GENOVA kit. The analysis of the data was done by Excel software. In this research, 225 samples have been studied. 106 women were positive while 118 women were negative. Furthermore, the most common high-risk genotypes were (16, 31, 33, 35, 39, 45, 52, 58, 59, and 67) and (18) while the most common low-risk genotypes were (40, 42, 43, 44, 54, 61, 62, 81, 83, and 89) and (6 and 11). Moreover, the maximum age range of positive women is between 28 and 35. This study has demonstrated that the determining of dangerous genotypes is considered an essential measure in managing people infected with HPV, especially persistent infection and prevention of cervical cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of the prevalent genotypes of human papillomavirus in the population of women in Golestan province in the northeastern of Iran

Vosoo,

Sarli,

Yousefi

et al. 2023

Cell. Mol. Biomed. Rep.

View full text Add to dashboard Cite

show abstract

Prevalence of human papillomavirus genotypes in women of different ethnicity from rural northwestern Ecuador

de los Ángeles Bayas-Rea,

Ponce,

Guenther

et al. 2024

BMC Global Public Health

View full text Add to dashboard Cite

Background In Ecuador, cervical cancer is the third most common cancer among women and the second most common cause of cancer-related death in women. Although HPV represents a serious public health problem worldwide, the information about its prevalence and genotypes in remote communities of Ecuador is limited. The aim of this study was to determine the distribution of HPV genotypes among ethnic minority women from two remote communities of the northwestern region of Ecuador: Afro-Ecuadorians and Chachis (Amerindian group). Methods We included 291 women who responded to a short survey and were screened for HPV by the amplification of the L1 gene and a nested multiplex PCR to detect 14 high risk (HR) genotypes. A survey collected information on ethnicity, age, community access, and sexual and gynecological history. We identified risk factors associated with HPV infection and co-infection using multivariate logistic regression to calculate odds ratio (OR) and Wald 95% confidence intervals (CI). Results Overall, HPV prevalence in the study cohort was 56%, and the five most common HR-HPV genotypes were HPV-58, -16, -68, -39, and -43; however, the distribution of HPV genotypes varied according to ethnicity. We identified lineage A (European variant) for HPV-16 and sublineage A2 for HPV-58 in both ethnic groups. Adjusting for ethnicity, age, community access, and number of sexual partners, we found that Afro-Ecuadorian women were less likely to have an HPV infection than Chachi women (OR: 0.49, 95% CI: 0.25, 0.96), and that participants in communities only accessible by river had 64% less chances of an HPV infection when compared to women in communities accessible by road (OR: 0.36, 95% CI: 0.19, 0.71), and women with 2 to 3 sexual partners had 2.47 times the odds of HPV infection than participants with 0–1 partners (OR: 2.47, 95% CI: 1.32, 4.6). Similar associations were observed with prevalence of co-infection. Conclusions This study provides baseline knowledge regarding the prevalence and distribution of HPV genotypes in ethnic groups of the northwestern coastal Ecuador and essential information for the implementation of appropriate HPV testing and vaccination program to prevent cervical cancer.

show abstract

Identification of human leukocyte antigen in precancerous and cancerous cervical lesions from Ecuadorian women

Cited by 2 publications

References 27 publications

Evaluation of the prevalent genotypes of human papillomavirus in the population of women in Golestan province in the northeastern of Iran

Evaluation of the prevalent genotypes of human papillomavirus in the population of women in Golestan province in the northeastern of Iran

Prevalence of human papillomavirus genotypes in women of different ethnicity from rural northwestern Ecuador

Contact Info

Product

Resources

About