Identification of Hub Genes in the Remodeling of Non-Infarcted Myocardium Following Acute Myocardial Infarction

Wang, Lingxiao; Zhang, Yan; Yu, Mengjie; Yuan, Wuzhou

doi:10.3390/jcdd9120409

Cited by 2 publications

(1 citation statement)

References 100 publications

(106 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…14,15 Moreover, the gene set of immune cells after myocardial infarction has been extensively studied for the diagnosis and prediction of myocardial infarction. [16][17][18][19] Recently, a series of novel inflammatory factors, such as IL-36, IL-37 and IL-38, were identified here. 20 Current studies have confirmed that these novel inflammatory factors are closely associated with the progression of atherosclerosis.…”

Section: Introductionmentioning

confidence: 97%

Serum IL-38 Level Was Associated with Incidence of MACE in the STEMI Patients

Lu¹,

Zhou²,

Xian³

et al. 2023

IJGM

View full text Add to dashboard Cite

Background The relationship between serum IL-38 and major adverse cardiovascular events (MACE) in patients with ST elevation myocardial infarction (STEMI) remains unclear. Methods In the present study, 589 STEMI patients were included, the serum level of IL-38 was measured. The median follow-up time was 720 days, the STEMI patients were divided into high IL-38 (IL-38>6.49ng/mL) and low IL-38 groups (IL-38≤6.49ng/mL) to compare the probability of MACE. Results Plasma IL-38 levels were significantly lower in STEMI patients than in SAP patients (4.0±2.2 vs 6.9±3.2 ng/mL, P < 0.001). Ninety-three STEMI patients met the defined MACE study endpoint. The incidence of MACE was significantly lower in patients with high IL-38 group than in patients with low IL-38 group (7.8% vs 23.7%, P < 0.001). Low plasma IL-38 levels were independently associated with the occurrence of MACE (OR = 0.90, P < 0.001). Conclusion We get a conclusion that low plasma levels of IL-38 are independently associated with the occurrence of MACE.

show abstract

Section: Introductionmentioning

confidence: 97%

Serum IL-38 Level Was Associated with Incidence of MACE in the STEMI Patients

Lu¹,

Zhou²,

Xian³

et al. 2023

IJGM

View full text Add to dashboard Cite

show abstract

The Influence of Metabolic Risk Factors on the Inflammatory Response Triggered by Myocardial Infarction: Bridging Pathophysiology to Treatment

Ramos-Regalado,

Alcover,

Badimon

et al. 2024

Cells

View full text Add to dashboard Cite

Myocardial infarction (MI) sets off a complex inflammatory cascade that is crucial for effective cardiac healing and scar formation. Yet, if this response becomes excessive or uncontrolled, it can lead to cardiovascular complications. This review aims to provide a comprehensive overview of the tightly regulated local inflammatory response triggered in the early post-MI phase involving cardiomyocytes, (myo)fibroblasts, endothelial cells, and infiltrating immune cells. Next, we explore how the bone marrow and extramedullary hematopoiesis (such as in the spleen) contribute to sustaining immune cell supply at a cardiac level. Lastly, we discuss recent findings on how metabolic cardiovascular risk factors, including hypercholesterolemia, hypertriglyceridemia, diabetes, and hypertension, disrupt this immunological response and explore the potential modulatory effects of lifestyle habits and pharmacological interventions. Understanding how different metabolic risk factors influence the inflammatory response triggered by MI and unraveling the underlying molecular and cellular mechanisms may pave the way for developing personalized therapeutic approaches based on the patient’s metabolic profile. Similarly, delving deeper into the impact of lifestyle modifications on the inflammatory response post-MI is crucial. These insights may enable the adoption of more effective strategies to manage post-MI inflammation and improve cardiovascular health outcomes in a holistic manner.

show abstract

Identification of Hub Genes in the Remodeling of Non-Infarcted Myocardium Following Acute Myocardial Infarction

Cited by 2 publications

References 100 publications

Serum IL-38 Level Was Associated with Incidence of MACE in the STEMI Patients

Serum IL-38 Level Was Associated with Incidence of MACE in the STEMI Patients

The Influence of Metabolic Risk Factors on the Inflammatory Response Triggered by Myocardial Infarction: Bridging Pathophysiology to Treatment

Contact Info

Product

Resources

About