Identification of hub genes and drug candidates for NF2-related vestibular schwannoma by bioinformatics tools
Jiasheng Yuan,
Yanpeng Fu,
Yuehui Liu
Abstract:Neurofibromatosis type 2 (NF2)-related vestibular schwannoma (NF2-VS) is a rare genetic disorder that results in bilateral acoustic neuromas. However, the exact pathogenesis of the disease is still unclear. This study aims to use bioinformatics analyses to identify potential hub genes and therapeutic. We retrieved the mRNA expression profiles (GSE108524 and GSE141801) of NF2-VS from the database, and selected the leading 25% genes with the most variance across samples for weighted correlation network analysis.… Show more
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