Abstract:ObjectivesTo identify endotypes in patients with infective endocarditis.MethodsThirty-two consecutive patients with infective endocarditis were studied. Clinical data and a blood sample were collected at diagnosis, and RNA sequenced. Gene expression was used to identify two clusters, termed endocarditis endotypes (EE) 1 and 2. RNA sequencing was repeated after surgery. Transcriptionally active cell populations were identified by deconvolution. Differences between endotypes in clinical data, survival, gene expr… Show more
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