Identification of High-Risk Patients Among Those Diagnosed With Thin Cutaneous Melanomas

Gimotty, Phyllis A.; Elder, David E.; Fraker, Douglas L.; Botbyl, Jeffrey; Sellers, Kimberly F.; Elenitsas, Rosalie; Ming, Michael E.; Schuchter, Lynn M.; Spitz, Francis R.; Czerniecki, Brian J.; Guerry, DuPont

doi:10.1200/jco.2006.08.1463

Cited by 188 publications

(180 citation statements)

References 28 publications

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“…Because disease can recur even among individuals with localized lesions despite appropriate surgical procedures, identifying independent prognostic markers in addition to stage at diagnosis has been a priority. Presently, nine additional independent clinicopathologic prognostic markers for CMM have been identified [e.g., age at presentation, gender, Breslow thickness (mm), Clark level of invasion, lesion ulceration, tumor-infiltrating lymphocyte status, presence of microsatellite lesions, degree of vascular and/or lymphatic invasion, and quantity of mitotic figures] and have been used to establish clinically validated risk stratifications among melanoma patients (2,3). Yet, in CMM (4,5), as well as in other cancers (6,7), the association of differential gene expression profiles with prognosis among histologically identical lesions has prompted the desire to enhance clinicopathologically derived prognostic models with molecular markers representative of the tumor subclasses.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Significance of Cadherin-Based Adhesion Molecules in Cutaneous Malignant Melanoma

Kreizenbeck¹,

Berger²,

Subtil³

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: The need for novel molecular prognostic markers that can supplement validated clinicopathologic correlates for cutaneous malignant melanoma is well recognized. Proteins that mediate the epithelialmesenchymal transition, the process by which a cancer cell disengages from its parent tumor, are important candidates. Methods: The prognostic relevance of E-cadherin, N-cadherin, and P-cadherin, calcium-dependent transmembrane glycoproteins that regulate cell-cell adhesion, and their adaptors, A-catenin, B-catenin, and p120-catenin, was evaluated on a cohort of 201 primary and 274 metastatic melanoma tumors using fluorescencebased immunohistochemical methods and Automated Quantitative Analysis of protein expression on digitally captured photomicrographs. Results: Increasing levels of N-cadherin expression improved overall survival (log-rank = 7.31; P = 0.03) but did not retain significance following adjustment for established clinicopathologic correlates (P = 0.50). Higher levels of E-cadherin approached significance for favorable prognosis on both univariate (P = 0.13)

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Section: Introductionmentioning

confidence: 99%

Prognostic Significance of Cadherin-Based Adhesion Molecules in Cutaneous Malignant Melanoma

Kreizenbeck¹,

Berger²,

Subtil³

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…4,10 Additionally, although most thin melanomas (Breslow thickness r1 mm) have a favorable prognosis, some thin melanomas are more aggressive; consequently, there is a need to identify thin melanomas with a more aggressive potential to guide management. 4,11,12 Insulin-like growth factor-II (IGF-II) messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the IGF-II mRNA-binding protein (IMP) family, which also includes IMP-1 and IMP-2. 13 IMP-3 is a 580 amino-acid protein encoded by a 4350-bp mRNA transcript produced by a gene located on chromosome 7p11.5.…”

mentioning

confidence: 99%

IMP-3 is a novel progression marker in malignant melanoma

et al. 2008

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Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family and is expressed during embryogenesis and in some malignancies. IMP-3 expression in melanocytic neoplasms has not been investigated. Fifty-six melanocytic neoplasms from 48 subjects were immunohistochemically studied using a monoclonal antibody against L523S/IMP-3. IMP-3 expression in melanoma was significantly higher than in Spitz nevi (Po0.05), and the staining intensity in the Spitz nevi was weak. IMP-3 expression in metastatic melanoma was significantly higher than in primary cutaneous melanoma with a Breslow depth r1 mm (Po0.01). None of the benign nevi and dysplastic nevi expressed IMP-3. Our study demonstrates that IMP-3 is expressed in malignant melanoma but not in benign nevi, even when dysplastic features are present; IMP-3 is expressed in a significantly higher proportion of melanomas than Spitz nevi; and IMP-3 is expressed in metastatic melanomas significantly more than in thin melanomas. In conclusion, IMP-3 appears to be involved in the progression of malignant melanoma and may play an important role in the regulation of the biologic behavior of this tumor. Additionally, IMP-3 may have diagnostic utility in distinguishing melanoma from benign nevic cells, dysplastic nevi, and Spitz nevi.

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“…Barnhill et al compared the values of MR vs. ulceration in predicting the prognosis of localized melanoma; multivariate analysis of MR, ulceration, and tumor thickness showed that MR (<1, 1−6, and >6) is the most independent prognostic factor. In addition, some other studies also confirmed that MR is an important prognostic factor of skin melanoma (25)(26)(27)(28). According to the AJCC staging system (2010 edition), patients with an MR value of ≥1 is an independent prognostic factor of poor prognosis, in particular in patients with an infiltration thickness of ≤1 mm.…”

Section: Pathology Reportmentioning

confidence: 84%

Chinese Guidelines on the Diagnosis and Treatment of Melanoma (2015 Edition)

et al. 2016

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Identification of High-Risk Patients Among Those Diagnosed With Thin Cutaneous Melanomas

Abstract: Prognostication and related clinical decision making in the majority of patients with melanoma can be improved now using the validated, SEER-based classification. Tumor cell mitotic rate should be incorporated into the next iteration of AJCC staging.

Cited by 188 publications

References 28 publications

Prognostic Significance of Cadherin-Based Adhesion Molecules in Cutaneous Malignant Melanoma

Prognostic Significance of Cadherin-Based Adhesion Molecules in Cutaneous Malignant Melanoma

IMP-3 is a novel progression marker in malignant melanoma

Chinese Guidelines on the Diagnosis and Treatment of Melanoma (2015 Edition)

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