Identification of hevein (Hev b 6.02) in Hevea latex as a major cross-reacting allergen with avocado fruit in patients with latex allergy

Chen, Zhiping; Posch, Anton; Cremer, Reinhold; Raulf‐Heimsoth, Monika; Baur, Xaver

doi:10.1016/s0091-6749(98)70138-1

Cited by 109 publications

(66 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These data indicate that Ole e 10 is an allergen per se. A notably allergenic capability has been reported for hevein, a small protein from latex and fruits, that constitutes the N-terminal module of both prohevein and class I chitinases (45)(46)(47). By contrast, Ole e 10 is not a part of Ole e 9, and a number of sensitizations were performed preferentially against one of these allergens indicating that both allergens may act as a primary sensitizer.…”

Section: Discussionmentioning

confidence: 99%

A Major Allergen from Pollen Defines a Novel Family of Plant Proteins and Shows Intra- and Interspecie Cross-Reactivity

Barral

Batanero

Palomares

et al. 2004

The Journal of Immunology

View full text Add to dashboard Cite

Olive tree (Olea europaea) pollen is a main cause of allergy associated with extensive areas of Europe and North America. Ole e 10, a small (10.8 kDa) and acidic (pI 5.8) protein, has been identified as a major allergen from the olive pollen, isolated, and characterized. Circular dichroism analysis gave 17% α helix, 33% β sheet, and 21% β turn for its secondary structure. Based on amino acid sequences of tryptic peptides, the protein was cloned and sequenced. The allergen consists of a single polypeptide chain of 102 aa, with a signal peptide of 21 residues. Ole e 10 showed homology with the C-terminal domain of another olive allergen, Ole e 9 (1,3-β-glucanase, 53% identity), with deduced sequences from Arabidopsis thaliana genes (42–46% identity) and with polypeptide segments (Cys boxes) of proteins involved in yeast development (Epd1/Gas-1p/Phr2 families; 42–43% similarity). Ole e 10 showed 55% prevalence for olive-allergic patients and exhibited an IgE response dependent on its conformation. Remarkable IgE cross-reactivity was detected with Ole e 9, but no correlation was observed between the individual IgE responses to both allergens. Ole e 10 shares IgE B cell epitopes with proteins from Oleaceae, Gramineae, Betulaceae, Chenopodiaceae, Cupressaceae, Ambrosia, and Parietaria pollens, latex, and vegetable foods, such as tomato, kiwi, potato, and peach. These data indicate that Ole e 10 is a new pan-allergenic plant protein that shows notable intra- and interspecie IgE cross-reactivity and is a powerful candidate to be involved in pollen-latex-fruit syndrome.

show abstract

Section: Discussionmentioning

confidence: 99%

A Major Allergen from Pollen Defines a Novel Family of Plant Proteins and Shows Intra- and Interspecie Cross-Reactivity

Barral

Batanero

Palomares

et al. 2004

The Journal of Immunology

View full text Add to dashboard Cite

show abstract

“…They were subjected to skin-prick testing with 19 common allergens (HAL, Dü sseldorf, Germany) and a self-made extract of ammoniated latex from Hevea brasiliensis [15], measurement of latex-specific IgE levels using the CAP system (Pharmacia, Uppsala, Sweden) and methacholine challenge testing as previously described [16]. Subjects with an immediate-type skin test response to latex and/or a respective CAP value of .0.35 kU?L -1 were defined as latex-sensitised.…”

Section: Methodsmentioning

confidence: 99%

Latex allergen exposure increases exhaled nitric oxide in symptomatic healthcare workers

Baur

Barbinova²

2005

European Respiratory Journal

View full text Add to dashboard Cite

The objective of this study was to investigate the clinical and diagnostic impact of baseline exhaled nitric oxide (eNO) levels and latex allergen-induced eNO changes in different healthcare worker groups.Healthcare workers, 31 latex-sensitised and 14 nonsensitised, underwent occupational-type challenge tests with powdered allergenic latex gloves.Sensitised as well as nonsensitised healthcare workers developed a significant eNO increase 1 h after challenge. Conversely, only latex-sensitised employees showed a significant eNO increase 22 h after challenge, which showed a significant relationship with bronchial obstruction (specific airway resistance changes). However, there was no difference in either baseline eNO level or eNO increase after 22 h between asthmatic (n513) and rhinitic only (n520) responders. The specificity and sensitivity of a 50% eNO increase after 22 h in responders were 100 and 56%, respectively.These results support the assumption that the whole respiratory tract is involved in a combined allergic rhinitis and asthma syndrome. Smoking healthcare workers showed reduced baseline exhaled nitric oxide levels, but, as shown for the first time, an allergen-induced exhaled nitric oxide increase comparable to that of nonsmokers. Corticosteroid therapy inhibited the allergeninduced exhaled nitric oxide change but not the clinical response in the challenge test. These findings suggest that cigarette smoke and corticosteroids initiate distinct molecular mechanisms influencing nitric oxide concentrations in the airways. KEYWORDS: Allergy, bronchial asthma, latex, nitric oxide E xhaled nitric oxide (eNO) has been described as a marker of allergic airway inflammation in both rhinitic and asthmatic subjects [1][2][3][4][5][6][7]. eNO levels may be elevated in patients before asthmatic symptoms develop [8,9]. HENRIKSEN et al. [8] and GRATZIOU et al.[9] observed a seasonal rise in eNO levels in pollensensitised subjects with and without rhinitic and/or asthmatic symptoms, with a tendency towards increased concentrations in symptomatic subjects.Despite the considerable number of publications and results indicating relations between baseline eNO level and/or eNO changes on the one hand and symptoms [9][10][11], bronchial hyperresponsiveness [12,13] and inflammatory parameters of the airways [14] on the other, the clinical role of eNO measurements has not been exactly defined. Moreover, the relation between eNO levels and eNO changes following laboratory allergen challenge has so far rarely been compared between subjects with rhinitic and those with asthmatic responses.The present hypothesis is that allergen-induced eNO increases have a clinical and diagnostic impact. Considering the influence of possible confounding factors such as atopy, smoking and corticosteroid therapy, it was investigated whether, in different patient subgroups, baseline eNO concentrations, as well as eNO changes, are associated with: 1) latex-specific immunoglobulin (Ig) E and skin-prick test responses; and 2) clinical responses...

show abstract

“…In the clinical history of some patients, the latex allergy has preceded the food allergy, whereas the converse is true in other patients. Structural homologies exist between Hev b 6 and wheat germ agglutinin [12] and between endochitinases in avocado [13] and banana [14].…”

Section: Cross-reactive Allergensmentioning

confidence: 99%

Occupational allergies caused by latex

Ahmed

Sobczak

Yunginger³

2003

Immunology and Allergy Clinics of North America

View full text Add to dashboard Cite

Identification of hevein (Hev b 6.02) in Hevea latex as a major cross-reacting allergen with avocado fruit in patients with latex allergy

Cited by 109 publications

References 23 publications

A Major Allergen from Pollen Defines a Novel Family of Plant Proteins and Shows Intra- and Interspecie Cross-Reactivity

A Major Allergen from Pollen Defines a Novel Family of Plant Proteins and Shows Intra- and Interspecie Cross-Reactivity

Latex allergen exposure increases exhaled nitric oxide in symptomatic healthcare workers

Occupational allergies caused by latex

Contact Info

Product

Resources

About