Identification of Hepatocellular Carcinoma-associated Hub Genes and Pathways by Integrated Microarray Analysis

Liu, Fangfeng; Li, Hongguang; Chang, Hong; Wang, Jianlu; Lü, Jun

doi:10.5301/tj.5000241

Cited by 30 publications

(18 citation statements)

References 45 publications

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“…This risk is dose and time-dependent and it is conditioned on the exposure mode. Oxidative stress, DNA methylation, the failure of DNA repair, activation of oncogenes, uncontrolled cell growth and the loss of apoptosis are among the mechanisms hypothesized by researchers [283][284][285][286] . Interestingly, Sabolić et al [287] have…”

Section: Cadmiummentioning

confidence: 99%

Hepatocellular carcinoma and the risk of occupational exposure

Rapisarda

Loreto

Malaguarnera

et al. 2016

WJH

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Hepatocellular carcinoma (HCC) is the most common type of liver cancer. The main risk factors for HCC are alcoholism, hepatitis B virus, hepatitis C virus, nonalcoholic steatohepatitis, obesity, type 2 diabetes, cirrhosis, aflatoxin, hemochromatosis, Wilson's disease and hemophilia. Occupational exposure to chemicals is another risk factor for HCC. Often the relationship between occupational risk and HCC is unclear and the reports are fragmented and inconsistent. This review aims to summarize the current knowledge regarding the association of infective and non-infective occupational risk exposure and HCC in order to encourage further research and draw attention to this global occupational public health problem. Core tip: Hepatocellular carcinoma (HCC) is the fifth most common human cancer. This review summarizes current knowledge regarding the occupational risk factors of HCC. In particular, we underline not only the infective but also non-infective occupational risk exposure, including chemical agents and toxic metabolites which are a major cause of liver damage.

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Section: Cadmiummentioning

confidence: 99%

Hepatocellular carcinoma and the risk of occupational exposure

Rapisarda

Loreto

Malaguarnera

et al. 2016

WJH

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“…[30][31][32][33][34][35] CDH1 and VEGFA have been reported among the highly significant markers in colorectal, gastric, and liver cancers. [36][37][38][39][40][41] The 154-gene expression signature shows clear promise in identifying the tumor's origin, but it is not perfect. For diagnostically challenging tumors, systematic errors were noted in the classes of endometrial and pancreatic tumors (58 and 61% misclassified, respectively).…”

Section: Discussionmentioning

confidence: 99%

Pan-cancer transcriptome analysis reveals a gene expression signature for the identification of tumor tissue origin

Xu¹,

Chen²,

et al. 2016

Modern Pathology

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Carcinoma of unknown primary, wherein metastatic disease is present without an identifiable primary site, accounts for~3-5% of all cancer diagnoses. Despite the development of multiple diagnostic workups, the success rate of primary site identification remains low. Determining the origin of tumor tissue is, thus, an important clinical application of molecular diagnostics. Previous studies have paved the way for gene expression-based tumor type classification. In this study, we have established a comprehensive database integrating microarray-and sequencing-based gene expression profiles of 16 674 tumor samples covering 22 common human tumor types. From this pan-cancer transcriptome database, we identified a 154-gene expression signature that discriminated the origin of tumor tissue with an overall leave-one-out cross-validation accuracy of 96.5%. The 154-gene expression signature was first validated on an independent test set consisting of 9626 primary tumors, of which 97.1% of cases were correctly classified. Furthermore, we tested the signature on a spectrum of diagnostically challenging tumors. An overall accuracy of 92% was achieved on the 1248 tumor specimens that were poorly differentiated, undifferentiated or from metastatic tumors. Thus, we have identified a 154-gene expression signature that can accurately classify a broad spectrum of tumor types. This gene panel may hold a promise to be a useful additional tool for the determination of the tumor origin.

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“…Aberrant DNA methylation is also an important mechanism in NASH progression [50] , and can lead to silencing of genes involved in DNA repair, lipid metabolism, glucose metabolism and progression of fibrosis [50] . In particular, the epigenetic changes in the gene encoding chromodomain helicase DNA-binding protein 1 are reported to be linked to NASH-associated HCC [51] .…”

Section: Genetic/epigenetic Mechanismsmentioning

confidence: 99%

Molecular links between non-alcoholic fatty liver disease and hepatocellular carcinoma

Raza¹,

Rajak²,

Anjum³

et al. 2019

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Non-alcoholic fatty liver disease (NAFLD) and its advanced complication, non-alcoholic steatohepatitis (NASH), have become leading causes of hepatocellular carcinoma (HCC) worldwide. In this review, we discuss the role of metabolic, gut microbial, immune and endocrine mediators which promote the progression of NAFLD to HCC. In particular, this progression involves multiple hits resulting from lipotoxicity, oxidative stress, inhibition of hepatic autophagy and inflammation. Furthermore, dysbiosis in the gut associated with obesity also promotes HCC via induction of proinflammatory cytokines and Toll like receptor signalling as well as altered bile metabolism. Additionally, compromised T-cell function and impaired hepatic hormonal action promote the development of NASH-associated HCC. Lastly, we discuss the current challenges involved in the diagnosis and treatment of NAFLD/NASH-associated HCC.

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Identification of Hepatocellular Carcinoma-associated Hub Genes and Pathways by Integrated Microarray Analysis

Abstract: Our study displayed genes that were consistently differentially expressed in HCC. The biological pathways and protein-protein interaction networks associated with those genes were also identified. We predicted that CDH1, ECHS1, ACAA1, MT2A, and MYC might be target genes for diagnosing HCC.

Cited by 30 publications

References 45 publications

Hepatocellular carcinoma and the risk of occupational exposure

Hepatocellular carcinoma and the risk of occupational exposure

Pan-cancer transcriptome analysis reveals a gene expression signature for the identification of tumor tissue origin

Molecular links between non-alcoholic fatty liver disease and hepatocellular carcinoma

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