Identification of hepatitis B virus and liver cancer bridge molecules based on functional module network

Huang, Xiaobing; He, Yonggang; Feng, Huan; Li, Yuming; Li, Hongyan; Yang, Fengxia; Li, Jing

doi:10.3748/wjg.v25.i33.4921

Cited by 4 publications

(6 citation statements)

References 47 publications

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“…Our recent study suggests that cinnamon improves liver function in diabetic mice by attenuating oxidative stress in liver tissue (Figure S1). Restoring liver function may further improve the regulation of genes and proteins involved in liver glucose metabolism signaling pathways and partially alleviate glucose metabolism disorders [7,8].…”

Section: Introductionmentioning

confidence: 99%

Effects of Cinnamon Powder on Glucose Metabolism in Diabetic Mice and the Molecular Mechanisms

Liu,

Xing

et al. 2023

Foods

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The liver is the primary organ regulating glucose metabolism. In our recent study, cinnamon improved liver function in diabetic mice. However, it is not clear whether cinnamon can reduce the glycemia of diabetic animals by regulating liver glucose metabolism. The purpose of this study was to investigate the hypoglycemic mechanism of cinnamon powder (CP) from the perspective of regulating liver glucose metabolism. To achieve this, different doses of CP (200, 400, or 800 mg/kg body weight) were given to diabetic mice by gavage once per day for 8 weeks. These mice were compared with healthy controls, untreated diabetic mice, and diabetic mice treated with metformin (the main first-line drug for type 2 diabetes). CP treatment effectively reduced fasting blood glucose levels and food intake, improved glucose tolerance and fasting serum insulin levels, and decreased glycated serum protein levels in diabetic mice. Furthermore, treatment with CP increased liver glycogen content and reduced the level of the gluconeogenesis precursor pyruvate in the liver. Data obtained by qPCR and western blotting suggested that CP improved glucose metabolism disorders by regulating AMPKα/PGC1α-mediated hepatic gluconeogenesis and PI3K/AKT-mediated hepatic glycogen synthesis. CP exhibits good hypoglycemic effects by improving hepatic glycogen synthesis and controlling hepatic gluconeogenesis. Therefore, CP may be applied as a functional food to decrease blood glucose.

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Section: Introductionmentioning

confidence: 99%

Effects of Cinnamon Powder on Glucose Metabolism in Diabetic Mice and the Molecular Mechanisms

Liu,

Xing

et al. 2023

Foods

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“… Sun et al (2019) characterized the genome size of HBV and HCV-infected HCC by comparing the publicly available data of the Cancer Genome Atlas Project (TCGA), comparing their gene expression patterns, methylation profiles, and copy number variation. Huang et al (2019) identified common gene disorders between HBV and HCC by screening DEGs. In addition, through modular methods such as PPI networks and hypergeometric tests, targeted drugs with regulatory effects on diseases are predicted.…”

Section: Discussionmentioning

confidence: 99%

“…On the one hand, during chronic inflammation caused by viral infections, a long-term abnormal expression of related proteins may induce physiological diseases and form a potential carcinogenic microenvironment. On the other hand, the occurrence and development of tumors also affect the inflammatory response process (Colotta et al, 2009;Huang et al, 2019). The global burden of hepatitis B virus (HBV) is enormous, with 257 million people chronically infected, causing more than 880,000 deaths worldwide each year (Iannacone and Guidotti, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…Overall, up to 40% of men and women infected with HBV during the perinatal period will die from cirrhosis or hepatocellular carcinoma ( Trépo et al, 2014 ; Schweitzer et al, 2015 ). There are many studies on the basis of clinical epidemiological studies on the mechanism of the relationship between hepatitis B and hepatitis B-related hepatocellular carcinoma, and significant progress has been made ( Huang et al, 2019 ; Sun et al, 2019 ; Xie et al, 2020 ). However, few molecular targeted studies can comprehensively summarize the diagnosis, treatment, and prognosis of patients with progressive hepatitis B.…”

Section: Introductionmentioning

confidence: 99%

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Identification of Key Genes Associated With the Process of Hepatitis B Inflammation and Cancer Transformation by Integrated Bioinformatics Analysis

et al. 2021

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BackgroundHepatocellular carcinoma (HCC) has become the main cause of cancer death worldwide. More than half of hepatocellular carcinoma developed from hepatitis B virus infection (HBV). The purpose of this study is to find the key genes in the transformation process of liver inflammation and cancer and to inhibit the development of chronic inflammation and the transformation from disease to cancer.MethodsTwo groups of GEO data (including normal/HBV and HBV/HBV-HCC) were selected for differential expression analysis. The differential expression genes of HBV-HCC in TCGA were verified to coincide with the above genes to obtain overlapping genes. Then, functional enrichment analysis, modular analysis, and survival analysis were carried out on the key genes.ResultsWe identified nine central genes (CDK1, MAD2L1, CCNA2, PTTG1, NEK2) that may be closely related to the transformation of hepatitis B. The survival and prognosis gene markers composed of PTTG1, MAD2L1, RRM2, TPX2, CDK1, NEK2, DEPDC1, and ZWINT were constructed, which performed well in predicting the overall survival rate.ConclusionThe findings of this study have certain guiding significance for further research on the transformation of hepatitis B inflammatory cancer, inhibition of chronic inflammation, and molecular targeted therapy of cancer.

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“…When the p value < 0.05, it can be considered that these cross-talk modules are more significant than random ones. In other words, there is a cross talk interaction between modules [13,14].…”

Section: Network Module Cross-talk Analysismentioning

confidence: 99%

Exploring molecular markers and drug candidates for colorectal cancer through comprehensive bioinformatics analysis

Zhu

Zhai

2023

Aging

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Colorectal cancer (CRC) often has a poor prognosis and identifying useful and novel agents for treating CRC is urgently required. This study aimed to examine molecular markers associated with CRC prognosis and to identify potential drug candidates. The differentially expressed genes (DEGs) of CRC in TCGA were identified. The genes associated with CRC, summarized from NCBI-gene, OMIM, and the DEGs, were used to construct a co-expression network by WGCNA. Moreover, the co-expression genes from modules of interest were used to carry out functional enrichment. A total of 2742 DEGs, including 1674 upregulated and 1068 downregulated genes, were identified. Thirteen co-expression modules were constructed with WGCNA. Brown and blue co-expression modules with significant differences in disease phenotype were found. Functional enrichment analysis showed that genes in the brown module were mainly related to cell cycle, cell proliferation, DNA replication, and RNA transport. The genes in the blue module were mainly associated with fatty acid degradation, sulfur metabolism, PPAR signaling pathway and bile secretion. In addition, both the genes in brown and blue were associated with tumor staging. Some prognostic markers and candidate small molecules drugs for CRC treatment were identified. In conclusion, we revealed molecular biomarker profiles in CRC by systematic bioinformatics analysis, constructed regulatory networks of mRNA, ncRNA and transcriptional regulators (TFs), and identified potential drugs targeting hub proteins and TFs.www.aging-us.com AGINGgenes involved in tumorigenesis and progression in CRC through WGNCA and to identify potential therapeutic drugs. AGING Table 3. Pivot (ncRNA)-module interaction pairs. Module ncRNA Connection P

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Identification of hepatitis B virus and liver cancer bridge molecules based on functional module network

Cited by 4 publications

References 47 publications

Effects of Cinnamon Powder on Glucose Metabolism in Diabetic Mice and the Molecular Mechanisms

Effects of Cinnamon Powder on Glucose Metabolism in Diabetic Mice and the Molecular Mechanisms

Identification of Key Genes Associated With the Process of Hepatitis B Inflammation and Cancer Transformation by Integrated Bioinformatics Analysis

Exploring molecular markers and drug candidates for colorectal cancer through comprehensive bioinformatics analysis

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