Identification of GPR35-associated metabolic characteristics through LC-MS/MS-based metabolomics and lipidomics
Qiqing Zhang,
Xian Zhao,
Siyuan Qin
et al.
Abstract:G protein-coupled receptor 35 (GPR35) has gained increasing attention as a promising target in treating inflammatory and gastrointestinal tract conditions, cardiovascular diseases, and cancer. Metabolites including kynurenic acid, lysophosphatidic acids, chemokine 17, and 5-hydroxyindole acetic acid have been suggested to be endogenous ligands of GPR35. However, little is known regarding the downstream metabolic characteristics upon GPR35 regulation. Herein, four GPR35 interventions in cell models, comprising … Show more
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