“…All the selected compounds, myxopyronin A and rifampin were docked into the switch region of bacterial RNAP (PDB ID: 3DXJ), and the binding energy was calculated by AutoDock 4.2 (Scripps Research Institute) (Morris et al., 2009). The negative and low binding energy values indicate strong interactions between the compounds and RNAP (Uddin, Zahra, & Azam, 2019). As illustrated in Table 6, compound 6e in complex with RNAP had the lowest binding energy value of −8.92 kcal/mol, whereas compounds 2g , 2h , 2k , 6f, and 6i had binding energies of −7.15, −7.69, −8.44, −8.22, and −6.20 kcal/mol, respectively.…”