Identification of Geranic Acid, a Tyrosinase Inhibitor in Lemongrass (Cymbopogon citratus)

Masuda, Toshiya; Odaka, Yuka; Ogawa, N; Nakamoto, Kentaro; Kuninaga, Hideki

doi:10.1021/jf072893l

Cited by 56 publications

(38 citation statements)

References 29 publications

(40 reference statements)

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“…Levels of citral, an α , β ‐unsaturated aldehyde, were lower than in lemongrass, and the neral to geranial ratio was favorable, as geranial has been shown to be the biologically active isomer . As nerolidol, (a sesquiterpene approved by the FDA as a food flavoring agent), exhibits antineoplastic, antimalarial and antileishmanial activity, and geranic acid (5.6%) has been shown to be a tyrosinase inhibitor, this essential oil may also have similar medicinal properties. The linalool contents in essential oils of cultivars ‘Rober's Lemon Rose’ (0.1%) and ‘Frensham’ (1.1%) were significantly lower than in cultivars ‘Bourbon’ (10.4%), ‘China’ (10.9%) and ‘Egypt’ (7.5%).…”

Section: Resultsmentioning

confidence: 99%

Insecticidal and biting deterrent activity of rose-scented geranium (Pelargoniumspp.) essential oils and individual compounds againstStephanitis pyrioidesandAedes aegypti

Alı

Murphy²,

Demirci

et al. 2013

Pest. Manag. Sci.

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Section: Resultsmentioning

confidence: 99%

Insecticidal and biting deterrent activity of rose-scented geranium (Pelargoniumspp.) essential oils and individual compounds againstStephanitis pyrioidesandAedes aegypti

Alı

Murphy²,

Demirci

et al. 2013

Pest. Manag. Sci.

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“…Infusions or decoctions derived from the leaves of this plant have been widely used as ethnomedicines for the treatment of inflammation, indigestion, nervous disorder, vascular disease, cancer, as well as other health problems (Francisco et al, 2011;Naika et al, 2010). Volatile compounds and polyphenols are reputed to be the main bioactive ingredients (Figueirinha et al, 2008;Masuda et al, 2008;Naika et al, 2010;Ravinder et al, 2010;Tzortzakis & Economakis, 2007).…”

Section: Introductionmentioning

confidence: 99%

Polysaccharides fromCymbopogon citratuswith antitumor and immunomodulatory activity

Bao

Yuan

Wang

et al. 2014

Pharmaceutical Biology

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Context: Most of the present studies on the antitumor efficiency of Cymbopogon citratus (DC.) Stapf (Gramineae) are limited to its low-mass compounds, and little information about the antitumor activity of polysaccharides from this plant is available. Objectives: This study focused on the potential antitumor and immunomodulatory activities of polysaccharides (CCPS) from C. citratus. Materials and methods: CCPS was isolated using the water extraction-ethanol precipitation method. The sarcoma 180 (S180) cells-inoculated mice were intraperitoneally administrated with CCPS (30-200 mg/kg/d) for seven consecutive days. The effects of CCPS on tumor growth, thymus and spleen weights, splenocyte proliferation, and cytokine secretion in the tumorbearing mice were measured. The cytotoxicity of CCPS (50-800 lg/mL) towards S180 cells was also studied. Results: CCPS significantly inhibited the growth of the transplanted S180 tumors, with the inhibition rates ranging from 14.8 to 37.8%. Simultaneously, CCPS dose-dependently improved the immunity of the tumor-bearing mice. With the highest dose of 200 mg/kg/d, the thymus and spleen indices were increased by 21.9 and 91.9%, respectively; ConA-and LSP-induced splenocyte proliferations were increased by 32.7 and 35.3%, respectively. The secretions of interleukin 2 (IL-2), interleukin 6 (IL-6), interleukin 2 (IL-12), and tumor necrosis factor-a (TNF-a) were increased by 103.2, 40.2, 23.6, and 26.3%, respectively. Nevertheless, almost no toxicity of CCPS towards S180 cells was observed, with the maximal inhibition rate less than 15% at the CCPS concentration of 800 lg/mL. Conclusion: CCPS exhibited antitumor activity in vivo, and this activity might be achieved by immunoenhancement rather than direct cytotoxicity.

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“…This browning sometimes results a loss of market value of the food products [29][30][31]. This browning sometimes results a loss of market value of the food products [29][30][31].…”

Section: Inhibitors Of Tyrosinasementioning

confidence: 99%

Novel Tyrosinase Inhibitors From Natural Resources - Their Computational Studies

Khan

2012

CMC

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Tyrosinase is a multi-copper enzyme widely distributed in different organisms, including plants & mammals, etc., which is responsible for pigmentations, undesired browning of fruits and vegetables. This is the key enzyme in the melanogenesis in human and molting process of insects. Therefore the inhibitors of the enzyme may lead to novel skin whitening agents, anti-browning substances or compounds for insect control. A large numbers of moderate to potent tyrosinase inhibitors have been reported during the last decade. From our group, we reported a number of potent inhibitors from synthetic, semi-synthetic and natural origins. The compounds are from several chemical classes, like phenolics, terpenes, steroids, chalcones, flavonoids, alkaloids, long-chain fatty acids, coumarins, sildenafil analogs, bipiperidines, biscoumarins, oxadiazole, tetraketones, etc. More recently, the crystal structure of mushroom and couple of other tyrosinases has been published and more recently the crystal structure of mushroom tyrosinase complexes with a highly potent inhibitor tropolone has been reported. Yet there is a lack of information of inhibitor-tyrosinase intermolecular interactions. To overcome such issues, some researchers started utilizing in silico tools, like molecular docking simulations, for such purposes. There are also few papers published about the successful utilization of computational tools like QSAR-based and ligand-based virtual screening to identify novel and potent inhibitors of the enzyme. In our group, we are using all possible computational tools, like ligand-based as well structure-based approaches, to identify new inhibitors. In this review, some of such examples are briefly described.

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Identification of Geranic Acid, a Tyrosinase Inhibitor in Lemongrass (Cymbopogon citratus)

Cited by 56 publications

References 29 publications

Insecticidal and biting deterrent activity of rose-scented geranium (Pelargoniumspp.) essential oils and individual compounds againstStephanitis pyrioidesandAedes aegypti

Insecticidal and biting deterrent activity of rose-scented geranium (Pelargoniumspp.) essential oils and individual compounds againstStephanitis pyrioidesandAedes aegypti

Polysaccharides fromCymbopogon citratuswith antitumor and immunomodulatory activity

Novel Tyrosinase Inhibitors From Natural Resources - Their Computational Studies

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