Identification of genomic structure variation based on Hi-C technology and its application in tumor research

Liu, Cong; Zhang, Zhihua

doi:10.1360/ssv-2019-0169

Cited by 3 publications

(3 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…RNA-seq (a sequence-based approach) has been the dominant technique in transcriptomics since the 2010s, and a recent study reported the transcriptome atlas of 16 Dezhou donkey tissues [ 57 ]. The uniqueness and specificity of chromosomal hierarchical units revealed a series of functional properties, such as cell cycle and gene regulation [ 58 ]. Hi-C technology is increasingly used in local variety formation and environmental adaptation studies [ 59 ].…”

Section: Sequencing and Assembly Of The Genomementioning

confidence: 99%

Origin, Evolution, and Research Development of Donkeys

Wang

Hua

Shi

et al. 2022

Genes

View full text Add to dashboard Cite

Lack of archaeological and whole-genome diversity data has restricted current knowledge of the evolutionary history of donkeys. With the advancement of science and technology, the discovery of archaeological evidence, the development of molecular genetics, and the improvement of whole-genome sequencing technology, the in-depth understanding of the origin and domestication of donkeys has been enhanced, however. Given the lack of systematic research, the present study carefully screened and collected multiple academic papers and books, journals, and literature on donkeys over the past 15 years. The origin and domestication of donkeys are reviewed in this paper from the aspects of basic information, cultural origin, bioarcheology, mitochondrial and chromosomal microsatellite sequences, and whole-genome sequence comparison. It also highlights and reviews genome assembly technology, by assembling the genome of an individual organism and comparing it with related sample genomes, which can be used to produce more accurate results through big data statistics, analysis, and computational correlation models. Background: The donkey industry in the world and especially in China is developing rapidly, and donkey farming is transforming gradually from the family farming model to large-scale, intensive, and integrated industrial operations, which could ensure the stability of product quality and quantity. However, theoretical research on donkey breeding and its technical development lags far behind that of other livestock, thereby limiting its industrial development. This review provides holistic information for the donkey industry and researchers, that could promote theoretical research, genomic selection (GS), and reproductive management of the donkey population.

show abstract

Section: Sequencing and Assembly Of The Genomementioning

confidence: 99%

Origin, Evolution, and Research Development of Donkeys

Wang

Hua

Shi

et al. 2022

Genes

View full text Add to dashboard Cite

show abstract

“…In addition, inGAP-sv allows users to determine the appearance of sequences and the color of lines, which makes structural variation research easier 19 . In recent years, it has become increasingly recognized that chromosomal structural variation is closely linked with the development and progression of many types of tumors, so software and platforms that visualize structural variation can continue to promote research in oncology and clinical medicine 20 .…”

Section: Fundamentals Of Bioinformatics Researchmentioning

confidence: 99%

Bioinformatics and its application: status and prospects

Shen

2022

International Conference on Biomedical and Intelligent Systems (IC-BIS 2022)

View full text Add to dashboard Cite

As an interdisciplinary science, bioinformatics draws methods and resources from the following disciplines by extracting valuable information and patterns: computer science, which provides the hardware and software for analysis; molecular biology, which is the source of the data to be analyzed; and mathematics, where the algorithms for data analysis originate. Bioinformatics greatly benefits omics research. It improves our knowledge of biological systems and contributes to our deep understanding of the genomes, growth, and development of microorganisms, animals, and plants. Using bioinformatics, we can advance human welfare by revolutionizing breeding methods, developing new drugs, or creating novel treatments for diseases. This article outlines and theoretical underpinnings of bioinformatics, analyzes its applications in agriculture and medicine in detail, identifies its unsolved issues, and puts forwards corresponding suggestions.

show abstract

“…中国科学院大学, 北京 100049 联系人, E-mail: junyu@big.ac.cn 收稿日期: 2020-04-13; 网络版发表日期: 2020-04-30 本期我们组织了6篇有领域代表性和写作特色的综述文章, 来"大写意"般地集中勾勒"染色质三维结构"这个近年来进展迅速、颇受关注的领域. 尽管文章数量不多, 却也有"包罗万象"之意: 有"如数家珍"式的研究要素介绍 [1] , 有"纵览全局"式的最新研究进展描述 [2] , 有"抽丝剥茧"般的"工具箱"揭底 [3] , 还有"一竿子插到底"的实际应用举例, 包括生物医学领域的应用 [4] 和专业研究领域的理论问题 [5] . 此外, 我们还提供了更宏观的"提纲挈领"式综述, 指出这个具体领域在目前科学前沿研究中的地位、发展方向, 以及对未来生命科学发展的贡献 [6] .…”

unclassified