Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P45 0IA1 gene

Kawajiri, Kaname; Nakachi, Kei; Imai, Kazue; Yoshii, Akira; Shinoda, Nahomi; Watanabe, Junko

doi:10.1016/0014-5793(90)80721-t

Cited by 428 publications

(232 citation statements)

References 8 publications

Supporting

Mentioning

220

Contrasting

Unclassified

Order By: Relevance

“…The CYP1A1 gene also plays an important role in the metabolism of estrogen in vivo, by catalyzing 2-hydroxylation. The 2-hydroxylation products (2-OH estradiol catechol and 2-OH estrone catechol) lack estrogenic activities (Kawajiri et al 1990). Furthermore, the 2-hydroxy catechol metabolites can be converted by Omethylation into 2-methoxy derivatives, which have been shown to possess anti-proliferative and anti-angiogenic properties (Cascorbi et al 1996;Crofts et al 1993).…”

Section: Introductionmentioning

confidence: 99%

Cytochrome P450 1A1 (CYP1A1) T3801C and A2455G polymorphisms in breast cancer risk: a meta-analysis

Chen

Huang

et al. 2007

J Hum Genet

View full text Add to dashboard Cite

The cytochrome P450 1A1 gene (CYP1A1), encoding Phase I metabolic enzymes, appeared to be a candidate gene for breast cancer risk. However, studies on the association between polymorphisms in this gene and breast cancer have yielded conflicting results. We performed a meta-analysis to investigate the association with breast cancer of the CYP1A1 polymorphisms T3801C (9,316 cases and 12,714 controls) and A2455G (9,552 cases and 9,320 controls). In the genotype contrast of A2455G, both additive [GG vs AA, P = 0.04, fixed-effects OR 0.72; 95% CI (0.53-0.99), P = 0.95 for heterogeneity] and recessive [GG vs (GA + AA), P = 0.04, fixed-effects OR 0.73; 95% CI (0.53-0.99), P = 0.97 for heterogeneity] models produced significant results in east-Asians. In premenopausal women in a worldwide population, significant association between A2455G and breast cancer was also found using both models [additive model: P = 0.02, fixedeffects OR 0.52; 95% CI (0.29-0.92), P = 0.39 for heterogeneity; recessive model: P = 0.02, fixed-effects OR 0.51; 95% CI (0.29-0.90), P = 0.38 for heterogeneity]. Our meta-analysis suggests that an A2455G G/G genotype is associated with a trend of reduced breast cancer risk, both in east-Asian women and in pre-menopausal women worldwide, while the T3801C C allele might not be a risk factor for breast cancer. Larger scale primary studies are required to further evaluate the interaction of CYP1A1 polymorphisms and breast cancer risk in specific populations.

show abstract

Section: Introductionmentioning

confidence: 99%

Cytochrome P450 1A1 (CYP1A1) T3801C and A2455G polymorphisms in breast cancer risk: a meta-analysis

Chen

Huang

et al. 2007

J Hum Genet

View full text Add to dashboard Cite

show abstract

“…Individuos expuestos a humo de cigarrillo y que han heredado el genotipo susceptible (GSTM1 o GSTT1 nulo) tendrían incrementada la carga corporal de metabolitos reactivos y, por lo tanto, un mayor riesgo de desarrollar cáncer de próstata 25,38 . En este estudio, en primer lugar examinamos la interacción entre los polimorfismos genéticos GSTM1, GSTT1 y CYP1A1, y posteriormente analizamos la interacción entre éstos y el hábito de fumar, y su asociación con el riesgo de cáncer de próstata.…”

Section: Discussionunclassified

“…Por otro lado, diversos autores han evaluado polimorfismos genéticos combinados de GSTM1, GSTT1 y riesgo de CaP. En general, no se han reportado asociaciones significativas entre combinaciones de los genotipos susceptibles para GSTM1, GSTT1 y riesgo de CaP 25,31 . Steinhoff y cols, en cambio, reportaron una significativa asociación entre estos polimorfismos y CaP 38 .…”

Section: Discussionunclassified

“…El ADN aislado de linfocitos periféricos se amplificó mediante la técnica de PCR usando partidores específicos que permiten la detección de las variantes alélicas en estudio 20,24 . El ADN amplificado se sometió a digestión con la enzima de restricción Msp1 a 37°C por 3 h. Finalmente se determinaron los polimorfismos Msp1 de CYP1A1 y las deleciones en los genes de GSTM1 y GSTT1 a través del análisis de fragmentos de restricción por electroforesis en gel de agarosa (2%) de acuerdo a metodologías previamente descritas 22,24,25 .…”

Section: Materials Y Métodounclassified

See 1 more Smart Citation

Interacciones genéticas y genético-ambientales como efecto modificador del riesgo de cáncer de próstata: un diseño «case-only»

C³

et al. 2004

Rev. méd. Chile

View full text Add to dashboard Cite

show abstract

“…Thus, the idea was considered to be a matter of controversy (13). Afterwards, the eŠects of genetic polymorphism of CYP1A1 on the lung cancer risk were demonstrated in Japanese by Kawajiri and his associates (14). This idea seemed to be reasona- Among many forms of cytochrome P450, CYP2A6 is known to be responsible for the metabolism of drugs including coumarin (18,19), nicotine (20), tegafur (21,22), fadrozole (23), methoxy‰urane (24) and valproic acid (25).…”

Section: Genetic Polymorphism Of Cyp and Cancer Riskmentioning

confidence: 99%

Genetic Polymorphism of CYP2A6 and Tobacco-Related Cancer Risk: From the Establishment of Genetically Engineered Salmonella to Large Scale Epidemiology

Kamataki

2006

Genes and Environment

View full text Add to dashboard Cite

Most mutagens/carcinogens are metabolically activated by enzymes such as cytochrome P450 to exert their mutagenicity or carcinogenicity. Since the catalytic properties of cytochrome P450 vary among animal species, it was necessary to establish a mutation-detection system carrying human cytochrome P450 to estimate if the chemicals are mutagenic in humans. For this purpose, we introduced genes for human cytochrome P450 together with NADPH-cytochrome P450 reductase to establish humanized Salmonella typhimurium. Using the genetically engineered Salmonella typhimurium, we found that CYP2A6 was involved in the metabolic activation of a variety of nitrosamines such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) contained in tobacco smoke. Analyzing the CYP2A6 gene of subjects who showed a poor metabolic phenotype towards (＋)-cis-3,5-dimethyl-2-(3-pyridyl)thiazoline-4-one hydrochloride (SM-12502), we discovered a novel mutant allele (CYP2A6*4C) lacking the whole CYP2A6 gene. Taking these results into account, we hypothesized that the subjects carrying the CYP2A6*4C allele had lower risk to tobacco-related lung cancer. In accordance with our hypothesis, our large scale epidemiological studies clearly indicated that smokers homozygous for the CYP2A6*4C allele showed much smaller odds ratios towards cancer risk. Other mutant alleles reducing the CYP2A6 activity besides the CYP2A6*4C allele also reduced the risk for lung cancer in smokers, particularly squamous cell carcinoma and small cell carcinoma frequently seen in smokers. 8-Methoxypsoralen, an inhibitor of CYP2A6, e‹ciently prevented the occurrence of adenoma caused by NNK in A/J mice.

show abstract

Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P45 0IA1 gene

Cited by 428 publications

References 8 publications

Cytochrome P450 1A1 (CYP1A1) T3801C and A2455G polymorphisms in breast cancer risk: a meta-analysis

Cytochrome P450 1A1 (CYP1A1) T3801C and A2455G polymorphisms in breast cancer risk: a meta-analysis

Interacciones genéticas y genético-ambientales como efecto modificador del riesgo de cáncer de próstata: un diseño «case-only»

Genetic Polymorphism of CYP2A6 and Tobacco-Related Cancer Risk: From the Establishment of Genetically Engineered Salmonella to Large Scale Epidemiology

Contact Info

Product

Resources

About