Identification of genetic variation in the lncRNA HOTAIR associated with HPV16-related cervical cancer pathogenesis

Saha, Sweta Sharma; Roy, Chowdhury; Mondal, NR; Chakravarty, Biman; Chatterjee, Tanmay; Roy, Sudipta; Sengupta, Shamik

doi:10.1007/s13402-016-0298-0

Cited by 38 publications

(23 citation statements)

References 61 publications

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“…The initial search yielded 337 publications, 262 of which were excluded for being irrelevant to HOTAIR polymorphisms, by reading titles and abstracts. On further evaluation, 37 articles were either biochemical studies or reviews and were therefore ruled out; 18 articles focused on non-cancer diseases such as rheumatoid arthritis and hearing loss; 1 article explored the relationship between cervical cancer risk and HOTAIR rs2366152 polymorphisms, which were not repeated in other published studies, resulting in the impossibility of data pooling; 22 and 1 article focused on the HOTAIR rs7958904 polymorphisms in lung cancer, but failed to offer detailed genotype information data. 23 Therefore, we enrolled 18 articles of 36 studies in this meta-analysis ( Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

The association between HOTAIR polymorphisms and cancer susceptibility: an updated systemic review and meta-analysis

Liu

et al. 2018

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ObjectivesThis work aims to explore whether HOX transcript antisense intergenic RNA (HOTAIR) polymorphisms are associated with cancer susceptibility.Materials and methodsA comprehensive search was conducted for literature published from January 2007 to July 2017. The pooled odds ratios (ORs) and the corresponding 95% CIs were calculated using the Revman 5.2 software. Eighteen articles of 36 case–control studies were enrolled including six HOTAIR polymorphisms and 10 cancer types.ResultsThe results showed that cancer risk was elevated in recessive mutation of rs12826786 (TT vs CC+CT: OR =1.55, 95% CI =1.19, 2.03; TT+CT vs CC: OR =1.23, 95% CI =1.04, 1.46; TT vs CC: OR =1.67, 95% CI =1.24, 2.24; T vs C: OR =1.24, 95% CI =1.09, 1.40) and rs920778 (TT vs CC+CT: OR =1.73, 95% CI =1.30, 2.30; TT+CT vs CC: OR =1.40, 95% CI =1.16, 1.70; TT vs CC: OR =1.83, 95% CI =1.25, 2.68; T vs C: OR =1.37, 95% CI =1.18, 1.59), while the results for polymorphisms of rs7958904, rs4759314, rs874945, and rs1899663 were insignificant. The stratified results for Chinese population were consistent with the overall group analysis.ConclusionOur meta-analysis showed that HOTAIR polymorphisms of rs12826786 and rs920778 were correlated with increased cancer risk, while rs7958904, rs4759314, rs874945, and rs1899663 were not. More studies with different types of cancer are needed to confirm the findings.

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Section: Resultsmentioning

confidence: 99%

The association between HOTAIR polymorphisms and cancer susceptibility: an updated systemic review and meta-analysis

Liu

et al. 2018

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“…LNMICC promoted lymph node metastasis of CC by recruiting NPM1 (a nuclear factor) to the promoter of FABP5 (a fatty acid binding protein) . Aberrant expression of lncRNA HOTAIR was associated with pathogenesis of HPV16‐related CC . Regarding the present study, a recently‐identified oncogene lncRNA TMPO antisense RNA 1 (TMPO‐AS1), located at chromosome 12q23.1, has attracted attention with respect to cancer therapies.…”

Section: Introductionmentioning

confidence: 81%

TMPO‐AS1 promotes cervical cancer progression by upregulating RAB14 via sponging miR‐577

Yang

Liang

Hou

2019

The Journal of Gene Medicine

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Background:Accumulating evidence has shown that long non-coding RNAs play a key role in cancer initiation and development. However, the effect of TMPO antisense RNA 1 (TMPO-AS1) on the progression of cervical cancer (CC) remains to be determined. Methods: The mRNA expression of TMPO-AS1, miR-577 and RAB14 was measured by a quantitative reverse transcriptase-polymerase chain reaction. The protein level of RAB14 was detected by western blotting. The function of TMPO-AS1 in CC was measured via Cell Counting Kit-8, 5-ethynyl-2′-deoxyuridine and transwell assays, as well as by flow cytometry analysis. Nuclear-cytoplasmic fractionation and RNA-fluorescence in situ hybridization validated the subcellular position of TMPO-AS1. An interaction between miR-577 and TMPO-AS1 or RAB14 was confirmed by luciferase reporter, RNA pull-down and RNA immunoprecipitation assays.Results: TMPO-AS1 was highly expressed in CC. In addition, TMPO-AS1 knockdown inhibited proliferation and migration, and also induced apoptosis. TMPO-AS1 located in the cytoplasm and promoted RAB14 expression by absorbing miR-577.RAB14 overexpression or miR-577 knockdown restored the suppressing effect of TMPO-AS1 knockdown on the biological behavior of CC cells. Conclusions:The present study has revealed a novel TMPO-AS1/miR-577/RAB14 regulatory axis in the pathogenesis of CC, highlighting TMPO-AS1 as a promising therapeutic target for CC patients.

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“…Moreover, some research on selected SNPs has been completed. The rs2366152C SNP on HOTAIR, for example, affected the secondary structure, with loss of the binding site for miR-22, in herpes virus (HPV)16-related cervical cancer development [76]. A novel risk SNP rs114020893 was predicted to change the secondary structure in the lncRNA NEXN-AS1 at 1p31.1, and may contribute to lung cancer susceptibility [77].…”

Section: Discussionmentioning

confidence: 99%

SNPs and Somatic Mutation on Long Non-Coding RNA: New Frontier in the Cancer Studies?

et al. 2018

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In the last decade, it has been demonstrated that long non-coding RNAs (lncRNAs) are involved in cancer development. The great majority of studies on lncRNAs report alterations, principally on their expression profiles, in several tumor types with respect to the normal tissues of origin. Conversely, since lncRNAs constitute a relatively novel class of RNAs compared to protein-coding transcripts (mRNAs), the landscape of their mutations and variations has not yet been extensively studied. However, in recent years an ever-increasing number of articles have described mutations of lncRNAs. Single-nucleotide polymorphisms (SNPs) that occur within the lncRNA transcripts can affect the structure and function of these RNA molecules, while the presence of a SNP in the promoter region of a lncRNA could alter its expression level. Also, somatic mutations that occur within lncRNAs have been shown to exert important effects in cancer and preliminary data are promising. Overall, the evidence suggests that SNPs and somatic mutation on lncRNAs may play a role in the pathogenesis of cancer, and indicates strong potential for further development of lncRNAs as biomarkers.

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Identification of genetic variation in the lncRNA HOTAIR associated with HPV16-related cervical cancer pathogenesis

Abstract: Our data indicate that rs2366152C not only has the potential to serve as a marker for singling out CaCx cases lacking metastatic molecular signatures, but also to explain the functional inactivation of HOTAIR in these cases, including the mechanism of its down-regulation.

Cited by 38 publications

References 61 publications

The association between HOTAIR polymorphisms and cancer susceptibility: an updated systemic review and meta-analysis

The association between HOTAIR polymorphisms and cancer susceptibility: an updated systemic review and meta-analysis

TMPO‐AS1 promotes cervical cancer progression by upregulating RAB14 via sponging miR‐577

SNPs and Somatic Mutation on Long Non-Coding RNA: New Frontier in the Cancer Studies?

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