Identification of Genetic Variants in ABCG2 Gene Influencing Milk Production Traits in Dairy Cattle

Singh, Arun Pratap; Chakravarty, A. K.; M, Mir; Arya, Ashwani; Singh, Manvendra

doi:10.18805/ijar.b-3770

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…These findings provide a strong foundation for further research involving in vitro and in vivo validation, as well as the discussion of sinensetin's potential as a therapeutic agent in the treatment of uric acid-related disorders. [45][46][47][48][49][50][51][52][53][54][55][56][57][58] Figure 2 and 3 depict the ligand sinensetin and ATP-binding cassette protein.…”

Section: Resultsmentioning

confidence: 99%

Study on the Inhibition of Sinensetin Extract from Cat's Whiskers Plant (Orthosiphon aristatus) on ATP Binding Cassette Sub-Family G Member 2 in Uric Acid

Faridah,

Verawati,

Oktavia

et al. 2023

Pharmacogn J.

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This study aims to investigate the potential of sinensetin, a compound found in the Cat's Whiskers plant (Orthosiphon aristatus), as an inhibitor in inhibiting uric acid through its interaction with ATP Binding Cassette Sub-Family G Member 2 (ABCG2). The in-silico approach was employed using software tools such as Pymol, PyRx, Protein Plus, and Lepinski Rule. The results of molecular docking analysis using PyRx demonstrated significant interactions between sinensetin and ABCG2, with Binding Affinity values of -6.8, -6.6, and -6.6, and RMSD values of 0, 0.785, and 1.379. The analysis using Protein Plus confirmed the interaction between sinensetin and ABCG2, supporting the previous docking findings. Furthermore, the evaluation of pharmacokinetic parameters using the Lepinski Rule of Five revealed that sinensetin meets the criteria as a potential drug compound, with a molecular weight of 372, no hydrogen bond donors, seven hydrogen bond acceptors, a log P value of 3.345, and a molar reactivity of 98.5. This research provides new insights into the development of uric acid therapy through an in-silico approach, and these findings can serve as a basis for further research involving in vitro and in vivo validation.

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Section: Resultsmentioning

confidence: 99%

Study on the Inhibition of Sinensetin Extract from Cat's Whiskers Plant (Orthosiphon aristatus) on ATP Binding Cassette Sub-Family G Member 2 in Uric Acid

Faridah,

Verawati,

Oktavia

et al. 2023

Pharmacogn J.

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“…It is possible to significantly accelerate the development of the dairy farming industry through using up-to-date technologies that accelerate the breeding process, establishing the interaction of the genotype and the environment and their impact on productivity, as well as increasing the share of the best genotypes in the population [7,8,9].…”

Section: Resultsmentioning

confidence: 99%

Scientific support and advanced research in dairy farming in the Russian Federation

Marinchenko

2021

E3S Web Conf.

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Increasing the output of agricultural products and improving their quality is one of the most important tasks of ensuring the food security of the Russian Federation. The solution to this problem is impossible without the introduction of up-to-date technologies that ensure the competitiveness and output growth, which are the result of scientific research and development. The basis for increasing the efficiency of dairy farming and, as a consequence, increasing milk production is the genetic improvement of the breeding base. The organization of selection and breeding work based on the use of our own genetic resources is a strategic task of the industry, which allows increasing the output of livestock products, reducing the technological import dependence of animal husbandry and minimizing the risk of the introduction of infectious diseases into the country. At the same time, the breeding base of dairy cattle breeding is on average 13.8% of the total livestock in the Russian Federation. The breeding progress is ensured by agricultural organizations, in which less than half of the total head of cows is concentrated. They are also the main consumers of research and development results. The purpose of the study is to analyze the state of the industry and its scientific potential, as well as formulate proposals for improving scientific support to create conditions for solving the tasks set by the state.

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Identification of Genetic Variants in ABCG2 Gene Influencing Milk Production Traits in Dairy Cattle

Cited by 2 publications

References 17 publications

Study on the Inhibition of Sinensetin Extract from Cat's Whiskers Plant (Orthosiphon aristatus) on ATP Binding Cassette Sub-Family G Member 2 in Uric Acid

Study on the Inhibition of Sinensetin Extract from Cat's Whiskers Plant (Orthosiphon aristatus) on ATP Binding Cassette Sub-Family G Member 2 in Uric Acid

Scientific support and advanced research in dairy farming in the Russian Federation

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