Identification of Genetic Links of Thyroid Cancer to the Neurodegenerative and Chronic Diseases Progression: Insights from Systems Biology Approach

Hossain, Md. Ali; Islam, Sheikh Muhammad Saiful; Akter, Tania; Hussain, Muhammad Sajjad; Rahman, Rezanur; Moustafa, Ahmed A.; Moni, Mohammad Ali

doi:10.1007/978-981-15-3607-6_21

Cited by 2 publications

(1 citation statement)

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“…A recent study found that the KEGG pathways Mineral absorption, Thyroid hormone synthesis, and Protein processing in the endoplasmic reticulum pathways and the GO molecular function terms protein tyrosine kinase activity, enzyme binding, protein binding, and integrin binding were enriched in follicular thyroid carcinoma [45]. Interestingly, emerging evidence has indicated possible molecular links between THCA and other diseases, such as Parkinson's disease, osteoporosis, chronic kidney disease, chronic heart failure, and Type 1 and Type 2 diabetes [46]. The Thyroid hormone synthesis, Adherens junction, and Thyroid cancer pathways were found to be common between THCA and chronic kidney disease [47].…”

Section: Discussionmentioning

confidence: 99%

Identification of hub genes in thyroid carcinoma to predict prognosis by integrated bioinformatics analysis

Pan

et al. 2021

Bioengineered

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The aim of this study was to identify hub genes closely related to the pathogenesis and prognosis of thyroid carcinoma (THCA) by integrated bioinformatics analysis. In this study, through differential gene expression analysis, 1916 and 665 differentially expressed genes (DEGs) were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database, and 7 and 11 co-expressed modules were identified from the TCGA-THCA and GSE153659 datasets, respectively, by weighted gene co-expression network analysis. We identified 162 overlapping genes between the DEGs and co-expression module genes as candidate hub genes. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses of the 162 overlapping DEGs identified significant functions and pathways of THCA, such as thyroid hormone generation and metabolic process. A protein-protein interaction (PPI) analysis detected the top 10 hub genes (QSOX1,

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Section: Discussionmentioning

confidence: 99%