Identification of genes associated with endometrial cell ageing

Kawamura, Teruhiko; Tomari, Hiroyuki; Onoyama, Ichiro; Araki, Hiromitsu; Yasunaga, Masafumi; Cui, Lin; Kawamura, Keiko; Yokota, Natsuko; Yagi, Hiroshi; Asanoma, Kazuo; Sonoda, Kenzo; Egashira, Kensuke; Ito, Takashi; Kato, Kanefusa

doi:10.1093/molehr/gaaa078

Cited by 10 publications

(15 citation statements)

References 34 publications

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“…It has been reported that deletion of Cxcl14 in mice could accelerate skeletal myogenesis by promoting cell cycle withdrawal, which may be a promising target for developing therapeutics to treat aging-related muscle wasting ( Waldemer-Streyer et al, 2017 ). And it has also been identified as a candidate marker for endometrial aging ( Kawamura et al, 2021 ). Besides, cxcl14 is an essential factor in the initial and maintenance of pain.…”

Section: Discussionmentioning

confidence: 99%

Identification of the common differentially expressed genes and pathogenesis between neuropathic pain and aging

Huang

et al. 2022

Front. Neurosci.

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BackgroundNeuropathic pain is a debilitating disease caused by damage or diseases of the somatosensory nervous system. Previous research has indicated potential associations between neuropathic pain and aging. However, the mechanisms by which they are interconnected remain unclear. In this study, we aim to identify the common differentially expressed genes (co-DEGs) between neuropathic pain and aging through integrated bioinformatics methods and further explore the underlying molecular mechanisms.MethodsThe microarray datasets GSE24982, GSE63442, and GSE63651 were downloaded from Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) and co-DEGs were first identified. Functional enrichment analyses, protein-protein Interaction (PPI) network, module construction and hub genes identification were performed. Immune infiltration analysis was conducted. Targeted transcription factors (TFs), microRNAs (miRNAs) and potential effective drug compounds for hub genes were also predicted.ResultsA total of 563 and 1,250 DEGs of neuropathic pain and aging were screened, respectively. 16 genes were further identified as co-DEGs. The functional analysis emphasizes the vital roles of the humoral immune response and complement and coagulation cascades in these two diseases. Cxcl14, Fblim1, RT1-Da, Serping1, Cfd, and Fcgr2b were identified as hub genes. Activated B cell, mast cell, activated dendritic cell, CD56 bright natural killer cell, effector memory CD8 + T cell, and type 2 T helper cell were significantly up-regulated in the pain and aging condition. Importantly, hub genes were found to correlate with the activated B cell, activated dendritic cell, Gamma delta T cell, central memory CD4 + T cell and mast cell in pain and aging diseases. Finally, Spic, miR-883-5p, and miR-363-5p et al. were predicted as the potential vital regulators for hub genes. Aldesleukin, Valziflocept, MGD-010, Cinryze, and Rhucin were the potential effective drugs in neuropathic pain and aging.ConclusionThis study identified co-DEGs, revealed molecular mechanisms, demonstrated the immune microenvironment, and predicted the possible TFs, miRNAs regulation networks and new drug targets for neuropathic pain and aging, providing novel insights into further research.

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Section: Discussionmentioning

confidence: 99%

Identification of the common differentially expressed genes and pathogenesis between neuropathic pain and aging

Huang

et al. 2022

Front. Neurosci.

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“…Recent studies indicate that CXCL14 overexpression promotes NK cell migration, cytotoxicity and infiltration [ 40 ], and is involved in thrombosis and platelet migration [ 41 ]. In addition, new evidence suggests that high expression of CXCL14 may cause endometrial cell aging [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Integrated analysis of 14 lymphoma datasets revealed high expression of CXCL14 promotes cell migration in mantle cell lymphoma

Liu

et al. 2022

Aging

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Lymphoma is accompanied by the impairment of multiple immune functions. Cytokines play an important role in a variety of immune-related functions and affect the tumor microenvironment. However, the exact regulatory mechanisms between them remain unclear. This study aimed to explore the cytokines expression and function in Hodgkin's lymphoma (HL), diffuse large B-cell lymphoma (DLBCL), and mantle cell lymphoma (MCL). We performed a transcriptome integration analysis of 14 lymphoma datasets including 240 Hodgkin's lymphoma, 891 diffuse large B-cell lymphoma, 216 mantle cell lymphoma, and 64 health samples. The results showed that multiple immune functions and signal pathway damage were shared by all three types of lymphoma, and these functions were related to cytokines. Furthermore, through co-expression network and functional interaction network analysis, we identified CXCL14 as a key regulator and it affects cell chemotaxis and migration functions. The functional experiment showed that CXCL14 knockdown inhibited cell migration in MCL cell lines. This study suggested that high expression of CXCL14 may aggravate MCL via promoting cell migration. Our findings provide novel insights into the biology of this disease and would be helpful for the pathogenesis study and drug discovery of lymphomas.

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“…These changes may be related to endometrial steroid receptors, altered blood flow, stromal angiosclerosis and other processes described in other animal species ( Melnick & Rosenwacks, 2018 ). A recent study showed that gene expression of proteins related to infammation and stemness is significantly higher in endometrial samples of patients in their 40s when compared with women in their 20s ( Kawamura et al ., 2021 ). Thus, these genes may be used as markers for endometrial aging and age-related infertility.…”

Section: Discussionmentioning

confidence: 99%

Donor oocyte cycle characteristics and outcomes: factors potentially linked with successful endings

Robin¹,

Andrade²,

Bös-Mikich³

et al. 2022

JBRA

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Objective: The use of donor oocytes in assisted reproduction has seen a significant rise worldwide in the last two decades. Postponement of motherhood and premature ovarian insufficiency are the main reasons for the increase in the number of in vitro fertilization cycles with donor oocytes. The present study aims to characterize donor oocyte cycles to analyze factors that may have an effect on live births and clinical pregnancy outcomes.Methods: Data were obtained from a single Assisted Reproduction Center in southern Brazil. Recipient demographics (n=148 patients) and cycle characteristics (n=213 cycles; 50 patients did more than one IVF attempt) were analyzed. Statistical analysis was performed using chi-squared and t-test as appropriate.Results: On average, recipients that reached gestation were significantly younger than the ones that did not. We also observed a significant positive effect of constant dose estrogen therapy on pregnancies.Conclusions: Patient age and response to estradiol therapy are important factors in the attainment of the best possible outcomes in cycles with donor oocytes.

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Identification of genes associated with endometrial cell ageing

Cited by 10 publications

References 34 publications

Identification of the common differentially expressed genes and pathogenesis between neuropathic pain and aging

Identification of the common differentially expressed genes and pathogenesis between neuropathic pain and aging

Integrated analysis of 14 lymphoma datasets revealed high expression of CXCL14 promotes cell migration in mantle cell lymphoma

Donor oocyte cycle characteristics and outcomes: factors potentially linked with successful endings

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