Identification of gene mutations associated with type 1 diabetes by next-generation sequencing in affected Palestinian families
Abrar Bawatneh,
Alaa Darwish,
Hasan Eideh
et al.
Abstract:Introduction: Diabetes Mellitus is a group of metabolic disorders characterized by hyperglycemia secondary to insulin resistance or deficiency. It is considered a major health problem worldwide. T1DM is a result of a combination of genetics, epigenetics, and environmental factors. Several genes have been associated with T1DM, including HLA, INS, CTLA4, and PTPN22. However, none of these findings have been based on linkage analysis because it is rare to find families with several diabetic individuals. Two Pales… Show more
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