Identification of gene fusions associated with amyotrophic lateral sclerosis
Yogindra Raghav,
Allison A. Dilliott,
Tiziana Petrozziello
et al.
Abstract:Introduction/AimsGenetics is an important risk factor for amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting motor neurons. Recent findings demonstrate that in addition to specific genetic mutations, structural variants caused by genetic instability can also play a causative role in ALS. Genomic instability can lead to deletions, duplications, insertions, inversions, and translocations in the genome, and these changes can sometimes lead to fusion of distinct genes into a single transcri… Show more
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