Identification of gastric related neurones in the rat insular cortex

Aleksandrov, V. G.; Bagaev, V. A.; Nozdrachev, A. D.; Panteleev, S. S.

doi:10.1016/0304-3940(96)12980-3

Cited by 21 publications

(2 citation statements)

References 11 publications

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“…The observed lack of statistically significant experimental effects on PRV immunolabeling in the BNST, CeA, or visceral cortices was unexpected, as these brain regions are also implicated in the central control of gastric function (Hermann et al, 1990, Aleksandrov et al, 1996, Yamamoto and Sawa, 2000, Liubashina et al, 2002, Zhang et al, 2003), and PRV transneuronal transport indicates that the developmental assembly of neuronal projections from these regions to gastric autonomic neurons is delayed by MS15 in neonatal rats (Card et al, 2005). However, potential PRV labeling differences within these relatively late-infected forebrain regions might emerge with longer post-inoculation intervals that produce more extensive transneuronal labeling.…”

Section: Discussionmentioning

confidence: 97%

“…Notably, Hans Selye’s original description of the “general adaptation syndrome” elicited by stress included prominent alterations in gastric function (Selye, 1936). Preautonomic regions such as the bed nucleus of the stria terminalis (BNST), central nucleus of the amygdala (CeA), paraventricular nucleus of the hypothalamus (PVN), and visceral cortices, [insular (IN) and prelimbic/infralimbic (PL/IL) cortex have been implicated in the central control of gastric function (Hermann et al, 1990, Aleksandrov et al, 1996, Yamamoto and Sawa, 2000, Liubashina et al, 2002, Zhang et al, 2003). In particular, experimental manipulation of the PVN in rats modifies the activity of gastric-related DVC neurons to alter gastric acid secretion and motility (Flanagan et al, 1992b, Zhang et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

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Repeated brief postnatal maternal separation enhances hypothalamic gastric autonomic circuits in juvenile rats

Banihashemi

Rinaman

2010

Neuroscience

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Maternal separation of rat pups for 15 minutes each day over the first one to two postnatal weeks (MS15) has been shown to increase the active maternal care received by pups and to decrease their later neuroendocrine and behavioral stress reactivity compared to non-separated (NS) controls. Stress responses prominently feature altered gastric secretion and motility, and we previously reported that the developmental assembly of forebrain circuits underlying gastric autonomic control, including gastric responses to stress, is delayed by MS15 in neonatal rats (Card et al. 2005, J. Neurosci. 25(40): 9102). To determine how this early delay affects the later organization of central gastric autonomic circuits, the present study examined the effects of neonatal MS15 on central pre-gastric circuits assessed in post-weaning, juvenile rats. For this purpose, the retrograde transynaptic viral tracer, pseudorabies virus (PRV), was microinjected into the stomach wall of 28-30 day old male rats with an earlier developmental history of either MS15 or NS. Rats were perfused 72 hours later and tissue was processed to reveal PRV-positive cells. Transynaptic PRV immunolabeling was quantified in selected preautonomic brainstem and forebrain regions, including the area postrema, bed nucleus of the stria terminalis, central nucleus of the amygdala, paraventricular nucleus of the hypothalamus (PVN), and visceral cortices. Compared to NS controls, MS15 rats displayed a significantly greater amount of PRV labeling within the PVN, including both the dorsal cap and ventral subnuclei. There were no postnatal group differences in the amount of PRV labeling within any other brain region examined in this study. This effect of MS15 to enhance hypothalamic preautonomic circuit structure indicates a strengthening of this pathway and may provide insight into how early life experience produces differential effects on later stress reactivity, including gastric secretory and motor responses to stress.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Repeated brief postnatal maternal separation enhances hypothalamic gastric autonomic circuits in juvenile rats

Banihashemi

Rinaman

2010

Neuroscience

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Conditioned place preference induced by electrical stimulation of the insular cortex: effects of naloxone

2013

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The insular cortex has been related to various sensory, regulatory, and learning processes, which frequently include affective-emotional components. The objective of this study was to investigate the possibility of inducing reinforcing effects by electrical stimulation of this cortical region in Wistar rats. Concurrent conditioned place preference tasks were conducted for this purpose, using two rectangular mazes that differed in dimensions, texture, and spatial orientation. A significant correlation was found in the preferences induced by insular cortex electrical stimulation between the two mazes. Animals showed consistent preference or avoidance behaviors associated with simultaneous insular cortex stimulation. No electrical self-stimulation was achieved. In a second experiment, animals that showed consistent place preference after the simultaneous insular cortex electrical stimulation were administered with 4 mg/ml/kg of naloxone. The results revealed that this opiate antagonist blocked concurrent place preference learning when the task was conducted in a new maze but not when it was conducted in the same maze as that in which the animals had learned the task. These results are discussed in terms of the participation of the insular cortex in various reward and aversion modalities.

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The insular cortex: a comparative perspective

2010

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The human insular cortex is involved in a variety of viscerosensory, visceromotor, and interoceptive functions, and plays a role in complex processes such as emotions, music, and language. Across mammals, the insula has considerable morphologic variability. We review the structure and connectivity of the insula in laboratory animals (mouse, domestic cat, macaque monkey), and we present original data on the morphology and cytoarchitecture of insular cortex in less common species including a large carnivore (the Atlantic walrus, Odobenus rosmarus), two artiodactyls (the pigmy hippopotamus, Hexaprotodon liberiensis, and the Western bongo, Tragelaphus eurycerus), two cetaceans (the beluga whale, Delphinapterus leucas, and the minke whale, Balaenoptera acutorostrata), and a sirenian (the Florida manatee, Trichechus manatus latirostris). The insula shows substantial variability in shape, extent, and gyral and sulcal patterns, as well as differences in laminar organization, cellular specialization, and structural association with the claustrum. Our observations reveal that the insular cortex is extremely variable among mammals. These differences could be related to the role exerted by specific and selective pressures on cortical structure during evolution. We conclude that it is not possible to identify a general model of organization for the mammalian insular cortex.

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Identification of gastric related neurones in the rat insular cortex

Cited by 21 publications

References 11 publications

Repeated brief postnatal maternal separation enhances hypothalamic gastric autonomic circuits in juvenile rats

Repeated brief postnatal maternal separation enhances hypothalamic gastric autonomic circuits in juvenile rats

Conditioned place preference induced by electrical stimulation of the insular cortex: effects of naloxone

The insular cortex: a comparative perspective

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