2016
DOI: 10.1039/c5ob02113h
|View full text |Cite
|
Sign up to set email alerts
|

Identification of gallic acid based glycoconjugates as a novel tubulin polymerization inhibitors

Abstract: A novel class of gallic acid based glycoconjugates were designed and synthesized as potential anticancer agents. Among all the compounds screened, compound 2a showed potent anticancer activity against breast cancer cells. The latter resulted in tubulin polymerization inhibition and induced G2/M cell cycle arrest, generation of reactive oxygen species, mitochondrial depolarization and subsequent apoptosis in breast cancer cells. In addition, ultraviolet-visible spectroscopy and fluorescence quenching studies of… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
14
0

Year Published

2016
2016
2021
2021

Publication Types

Select...
7

Relationship

2
5

Authors

Journals

citations
Cited by 26 publications
(14 citation statements)
references
References 97 publications
0
14
0
Order By: Relevance
“…In addition, 13 CNMR spectrum revealed five quaternary carbons at δ 121.4 (C-1), 109.8 (C-2, 6), 146.0 (C-3, 5), 140.3(C-4) and 167.3 (C = O). Based on the spectroscopic data and by comparing to the published literature, 38 this compound was identified as GA.…”
Section: Resultsmentioning
confidence: 97%
“…In addition, 13 CNMR spectrum revealed five quaternary carbons at δ 121.4 (C-1), 109.8 (C-2, 6), 146.0 (C-3, 5), 140.3(C-4) and 167.3 (C = O). Based on the spectroscopic data and by comparing to the published literature, 38 this compound was identified as GA.…”
Section: Resultsmentioning
confidence: 97%
“…Mitochondria are critical for regulation of cell death and the intrinsic apoptotic pathway is dependent on disruption of mitochondria . Treatment of MDA‐MB‐231 cells with compound 35 and analysis with Jc‐1 dye showed that compound 35 induced significant loss of mitochondrial membrane potential (Figure ) suggesting that compound 35 induced apoptosis involves mitochondrial dysfunction.…”
Section: Resultsmentioning
confidence: 99%
“…Tumour size and body weight were measured on every fifth day. Tumour volume was calculated using formula, V = [(Length) × (Width)2]/2 . Finally, tumours and other organs were collected in RNA later as well as 10% neutral‐buffered formalin while lungs were collected in Bouin's solution .…”
Section: Methodsmentioning
confidence: 99%