Identification of five frailty profiles in community-dwelling individuals aged 50–75: A latent class analysis of the SUCCEED survey data

Segaux, Lauriane; Oubaya, Nadia; Broussier, Amaury; Baude, Mathilde; Canouï‐Poitrine, Florence; Naga, Henri; Laurent, Marie; Leissing-Desprez, Claire; Audureau, Étienne; Ferrat, Émilie; Chailloleau, Christophe; Fromentin, Isabelle; David, Jean‐Philippe; Bastuji‐Garin, Sylvie

doi:10.1016/j.maturitas.2019.05.007

Cited by 11 publications

(8 citation statements)

References 32 publications

(51 reference statements)

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“…In fact, the close relationship between the frailty phenotype and depression is not surprising given the shared criterion of 'exhaustion' in the measure of depression (Fried et al, 2001). Physical frailty, cognitive impairment and depression are interrelated constructs (Mezuk, Lohman, Dumenci, & Lapane, 2013;Segaux et al, 2019) and they…”

Section: Discussionmentioning

confidence: 99%

“…In fact, the close relationship between the frailty phenotype and depression is not surprising given the shared criterion of ‘exhaustion’ in the measure of depression (Fried et al., 2001). Physical frailty, cognitive impairment and depression are interrelated constructs (Mezuk, Lohman, Dumenci, & Lapane, 2013; Segaux et al., 2019) and they share several common underlying pathophysiologic mechanisms, including subclinical cerebrovascular diseases, chronic inflammation and hypothalamic–pituitary axis stress response dysfunction (Panza et al., 2018; Vaughan et al., 2015). The strong relationship between depression and cognitive frailty found in this study suggests that clinicians, especially those working in primary care, should perform holistic assessment and care in terms of the physical, cognitive and psychological aspects to meet the multidimensional healthcare needs of the older vulnerable population.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence and risk factors of the co‐occurrence of physical frailty and cognitive impairment in Chinese community‐dwelling older adults

Xie

Chen

et al. 2020

Health Soc Care Community

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This cross-sectional study aimed to determine the prevalence of the co-occurrence of physical frailty and cognitive impairment and to identify its associated demographic, psychosocial and behavioural factors. Participants were recruited from 32 neighbourhoods using multistage sampling method in Xuhui District, Shanghai, China. A total of 1585 older adults were included who lived in community, were 75 years or older and without a clinical diagnosis of dementia. Based on the presences of frailty (using the modified frailty phenotype criteria) and/or cognitive impairment (using Chinese version Mini-Mental Status Examination stratified by educational level), the participants were classified into four groups: normal, cognitive impairment alone, frailty alone and co-occurrence. Multinomial logistic regression analyses were conducted to identify the demographic, psychosocial (depression, social participation and social support) and behavioural (sedentary lifestyle and sleep problems) characteristics associated with the co-occurrence of physical frailty and cognitive impairment. The prevalence of frailty alone, cognitive impairment alone and the co-occurrence of physical frailty and cognitive impairment in the study sample were 7%, 26.94% and 7.19% respectively. The results of multinomial logistic regression show the following characteristics significantly associated with the co-occurrence of physical frailty

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prevalence and risk factors of the co‐occurrence of physical frailty and cognitive impairment in Chinese community‐dwelling older adults

Xie

Chen

et al. 2020

Health Soc Care Community

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“…We analyzed baseline data from the SUCCEED survey 18 of community-dwellers aged ≥50, free of dementia and cognitive complaints, and consecutively assessed at an outpatient clinic in a 3000-bed university hospital in the greater Paris area of France. Individuals underwent a multidimensional geriatric assessment (including evaluations of cognition, mood, balance, mobility, muscle strength, nutrition, comorbidities, and bone density) and brain MRI.…”

Section: Study Populationmentioning

confidence: 99%

Understated Cognitive Impairment Assessed with the Clock-Drawing Test in Community-Dwelling Individuals Aged ≥50 Years

Leissing-Desprez

Thomas

Segaux

et al. 2020

Journal of the American Medical Directors Association

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Objectives: To estimate the prevalence of understated cognitive impairment by administering the Clock-Drawing Test (CDT) to community-dwelling individuals aged ≥50, and to investigate the associated clinical phenotype. Design: A cross-sectional analysis of baseline data on community-dwelling individuals assessed at an outpatient clinic in the Paris region of France. Setting and Participants: Participants aged ≥50 (n=488, median age: 62.1) prospectively included in the SUCCEED survey between 2010 and 2014. Methods: A multidimensional geriatric assessment, including cognition (7-point CDT, MMSE, the 5-word screening test (5-WT), and the Frontal Assessment Battery (FAB)), gait speed in dual tasks, mood (the Geriatric Depression Scale (GDS)), balance, physical functions (gait speed and handgrip strength), nutrition, bone density, and comorbidities; major cardiovascular risk factors, and Scheltens and Fazekas scores on brain MRI. Baseline characteristics were analyzed as a function of the CDT score (<7 versus 7), using ageadjusted logistic models.

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“…These findings could be masked when using an overall frailty label and could give some explanation to another gender-related condition in the existing bibliography, the higher mortality among men resulting from frailty [ 18 , 51 , 52 ]. Sex-specific pathways to frailty could also explain specific gender-related profiles [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, the studies on frailty profiles have used a variety of indicators to get the profiles. Some of these studies only used Fried’s criteria [ 13 , 14 , 15 , 16 , 18 ], while others included psychosocial indicators of frailty and/or related problems [ 3 , 11 , 17 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Frailty Status Typologies in Spanish Older Population: Associations with Successful Aging

Tomás

Sentandreu‐Mañó

Fernández

2020

IJERPH

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Background: Defining frailty typologies would contribute to guiding specific care interventions. These typologies could additionally be related to different health outcomes. This study aims at identifying subgroups of frail older adults based on the physical frailty phenotype and examining the relationships of these frailty profiles with quality of life and perceived health. Methods: This study relies on data from the SHARE project, namely a representative sample of 1765 Spanish-dwelling older adults identified as frail or pre-frail. Analysis included general descriptive statistics, exploratory latent class analysis (LCA) to determine the number of frailty subgroups, and LCA with covariates to examine differential relationships with markers of successful aging. Results: Statistical criteria and interpretability of the classes suggested that the LCA model with four classes should be retained. Class 1 was identified as the “frail people” group, Class 2 “activity problems” group, Class 3 “fatigued” group, and those belonging to Class 4 “lack of strength” group. Final LCA with covariates showed lower levels of quality of life and perceived health of the “frail” as compared to other frailty subgroups. Conclusion: This study revealed four different patterns of frailty attributes and further offered evidence on individuals’ differential status of health regarding distinct frailty conditions.

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Identification of five frailty profiles in community-dwelling individuals aged 50–75: A latent class analysis of the SUCCEED survey data

Cited by 11 publications

References 32 publications

Prevalence and risk factors of the co‐occurrence of physical frailty and cognitive impairment in Chinese community‐dwelling older adults

Prevalence and risk factors of the co‐occurrence of physical frailty and cognitive impairment in Chinese community‐dwelling older adults

Understated Cognitive Impairment Assessed with the Clock-Drawing Test in Community-Dwelling Individuals Aged ≥50 Years

Frailty Status Typologies in Spanish Older Population: Associations with Successful Aging

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